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This is an archive article published on September 4, 2007

First individual human genome decoded

The first individual genome ever sequenced has revealed genetic variation among humans far richer than previously imagined.

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The first individual genome ever sequenced 8212; a complete DNA blueprint of celebrity scientist Craig Venter 8212; has revealed genetic variation among humans far richer than previously imagined.

Published on Tuesday in the online open-access journal PloS Biology, the 2.8 billion contiguous bits of genetic code will also hasten advances in preventative medicine, said Venter, who is both an author and the object of the study.

Within five years, faster and cheaper sequencing techniques could produce complete genomes for 10,000 people, laying the foundation for 8220;an era of individualized genomics,8221; he predicted.

8220;Once we have those, we will basically be able to sort out every fundamental question about nature versus nurture, what8217;s genetic and what8217;s environment,8221; he said by phone.

The findings overturn what had in a few short years become genetic gospel: that all human beings are, genetically speaking, 99.9 per cent identical.

Venter himself trumpeted this idea in 2000 when his biotech firm Celera, which he left in 2003, and a team of US-government scientists simultaneously unveiled 8212; after a bruising race to the finish line 8212; the fist complete human genome.

Both of these earlier efforts were flawed and greatly underestimated genetic diversity, he and his colleagues now say, because the whole had been assembled from a hodgepodge of DNA taken from several individuals.

 

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