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This is an archive article published on April 21, 2021

Covaxin neutralises double mutant strain of SARS-CoV-2: ICMR study

ICMR scientists have said that the NIV has demonstrated the neutralization potential of Covaxin against the UK variant and Brazil variant.

covaxin, coronavirus vaccine, Haffkine Pharmaceutical, india news, indian expressCovaxin has been manufactured by Hyderabad-based Bharat Biotech. (File)

Covid-19 vaccine Covaxin, which is made by Bharat Biotech, has been found to effectively neutralise the double mutant strain, B.1.617, of SARS-CoV-2 and other variants, the Indian Council of Medical Research (ICMR) has said.

Dr Samiran Panda, chief of epidemiology and communicable diseases division of ICMR, said it is good news and hoped that there will be less anxiety among people in the second wave with this new information about the vaccine. Covaxin has been found to effectively neutralise the double mutant strain also apart from other variants of concern, Dr Panda said.

At ICMR-National Institute of Virology, scientists said they have isolated and cultured the double mutant strain which has E484Q and L452R mutations. They have also isolated and cultured all variants of concern of SARS-CoV-2 virus: B.1.1.7 (UK variant); B.1.1.28.2 (Brazil variant) and B.1.351 (South African variant), the scientists said.

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ICMR scientists said the NIV has demonstrated the neutralisation potential of Covaxin against the UK variant and Brazil variant. The data for the South African variant is being generated. Recently, ICMR-NIV successfully isolated and cultured the double mutant strain B.1.617 (E484Q and L452R) prevalent in certain regions of India.

Bharat Biotech also tweeted that with the accelerated Phase 3 vaccination schedule starting on May 1, it is essential to know the answers to vaccine efficacy and listed details in their blog.

Anuradha Mascarenhas is a Senior Editor at The Indian Express, based in Pune. With a career spanning three decades, she is one of the most respected voices in Indian journalism regarding healthcare, science and environment and research developments. She also takes a keen interest in covering women's issues . Professional Background Education: A gold medalist in Communication and Journalism from Savitribai Phule Pune University and a Master’s degree in Literature. Author: She authored the biography At The Wheel Of Research, which chronicles the life and work of Dr. Soumya Swaminathan, the former Chief Scientist at the WHO. Key Focus: She combines scientific accuracy with storytelling, translating complex medical research into compelling public and human-interest narratives. Awards and Recognition Anuradha has won several awards including the Press Council of India's national award for excellence in journalism under the gender based reporting category in 2019 and the Laadli Media award (gender sensitivity -2024). A recipient of the Lokmat journalism award (gender category-2022), she was also shortlisted for the RedInk awards for excellence in journalism-2021. Her debut book At The Wheel Of Research, an exclusive biography of Dr Soumya Swaminathan the inaugural chief scientist of World Health Organisation was also nominated in the Popular Choice Category of JK Paper AUTHER awards. She has also secured competitive fellowships including the Laadli Media Fellowship (2022), the Survivors Against TB – New Research in TB Media Fellowship (2023) and is part of the prestigious 2025 India Cohort of the WomenLift Health Leadership Journey.” Recent Notable Articles (Late 2025) 1. Cancer & Specialized Medical Care "Tata Memorial finds way to kill drug-resistant cancer cells" (Nov 26, 2025): Reporting on a breakthrough for triple-negative breast cancer, one of the most aggressive forms of the disease. ``Discipline, diet and purpose; How a 97-year-old professor defies ageing'' (Nov 15, 2025) Report about Prof Gururaj Mutalik, the first Head of Department at Pune's B J Government Medical College who at 97 credits his longevity to healthy habits and a strong sense of purpose. 2. Environmental Health (The "Breathless Pune" Series) "Long-term exposure even to 'moderate' air leads to chronic heart, lung, kidney issues" (Nov 26, 2025): Part of an investigative series highlighting that even "safe" pollution levels are damaging to vital organs. "For every 10 µg/m3 increase in PM2.5 level, there was 6-8% jump in medicine sales" (Nov 23, 2025): Using commercial data to prove the direct link between air quality and respiratory illnesses in Pune. 3. Lifestyle & Wellness News "They didn't let cancer, diabetes and heart disease stop them from travelling" (Dec 22, 2025): A collaborative piece featuring survivors who share practical tips for traveling with chronic conditions. ``At 17, his BP shot up to 200/120 mmHG; Lancet study flags why child and teen hypertension doubled between 2000 and 2020'' (Nov 12,2025)--A report that focusses on 17-year-old-boy's hypertensive crisis and reflects the rising global trend of high blood pressure among children and adolescents. 4. Scientific Recognition & Infrastructure "For promoting sci-comm, gender diversity: IUCAA woman prof highlighted in Nature" (Nov 25, 2025): Covering the global recognition of Indian women scientists in gender studies and physics. ``Pune researchers find a spiral galaxy like the Milky Way from early universe'' (December 3, 2025)- A report on how Indian researchers discovered a massive galaxy that existed when the universe was just 1.5 billion years old , one of the earliest to have been observed so far. Signature Beat: Health, Science & Women in Leadership Anuradha is known for her COVID-19 reportage, where she was one of the first journalists to provide detailed insights into the Covishield and Covaxin trials. She has a dedicated interest in gender diversity in health and science, often profiling women researchers who are breaking the "leaky pipeline" in STEM fields. Her writing style is scrupulous, often featuring interviews with top-tier scientists and health experts from various institutions. X (Twitter): @runaanu   ... Read More

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