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This is an archive article published on March 11, 2023

H3N2 virus spread: How to distinguish it from adenovirus? Is pollution to blame?

Particulate matter weakens the lungs and makes it easier for the virus to manifest itself with more severity, says Dr Ajay Aggarwal, Director, Internal Medicine, Fortis Hospital, Noida

H3N2 is a new influenza virus. We have been too focussed on the Corona virus but remember that all other flu viruses keep on changing their genetic strains. (Pic source: Getty)H3N2 is a new influenza virus. We have been too focussed on the Corona virus but remember that all other flu viruses keep on changing their genetic strains. (Pic source: Getty)
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H3N2 virus spread: How to distinguish it from adenovirus? Is pollution to blame?
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Amid the two deaths recorded in Karnataka and Haryana due to the Influenza A subtype H3N2 virus, its rapid spread across India has been a cause of concern. But experts say that much of the spread has got to do with atmospheric pollution. “The low humidity and high concentrations of pollutants are causing the high levels of transmission,” says Dr Ajay Aggarwal, Director, Internal Medicine, Fortis Hospital, Noida.

Why are we seeing a surge in the number of flu cases? Is it unusual? “This year, we are seeing a surge in the number of flu cases. This can be attributed to the low temperature along with low humidity conditions prevailing now in Delhi-NCR. Often low humidity is conducive for virus transmission. Also, the high pollution levels are causing people to develop more respiratory infections that are making their lung health susceptible to viral attacks. Another plausible explanation may be the decline in immunity post-Covid but that is still being studied,” adds he.

So how does air pollution cause the H3N2 virus to spread faster? “That association has been proven by many studies. Particulate matter in the air is worrying. Tiny particles, both liquids and solids, float about in the air and are so small that they can penetrate both the lungs and blood stream and do considerable damage. They weaken the lungs and make it easier for the virus to manifest itself with more severity.

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A study by the Harvard TH Chan School of Public Health had found that breathing more polluted air over many years could worsen the effects of viruses like COVID-19. That study had found an association between air pollution over many years with a 11 per cent increase in mortality from COVID-19 infection for every 1 microgram/cubic meter increase in air pollution. Another study way back in 2007 had shown how exposure to air pollutants can induce oxidative stress, resulting in the production of free radicals, which in turn, can damage the respiratory system, reducing the resistance to viral and bacterial infections,” says Dr Aggarwal.

“Chemicals also affect pathogens and can make them more dangerous,” he adds. Researchers have shown a link between multidrug-resistant bacteria and exposure to zinc, lead and disinfectants. Mercury and arsenic are known to alter the immune response and increase susceptibility to infectious diseases in multiple species of laboratory animals. Epidemiological studies in humans have linked exposure to various chemicals in the womb with reduced levels of antibodies triggered by childhood vaccines and increased risk of infectious diseases.

The other big problem in managing spiralling numbers is the cocktail of viruses circulating, particularly adenovirus. How do we spot the difference? “Both influenza and adenovirus are circulating in the air and it is difficult to differentiate between the two. Often the two present themselves as typical viral prodromes or early indications of the onset of the disease. However, adenovirus infections are often accompanied by pink eyes as well. And they could be milder,” adds Dr Aggarwal.

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