The WHO cautioned that “we have seen broad variations in naïve estimations of CFR that may be misleading”. Adjusting for the stage of the pandemic in each setting is essential to correctly interpreting COVID-19 statistics.
With the spike protein having multiple locations where antibodies can bind and neutralise the virus, mutations in the pathogen are not likely to be easily successful in negotiating the vaccine.
The recipe for the earlier successes included close technical coordination between central, state and municipal agencies as well as a proactive political leadership, ably backed by a strong public health establishment of the Municipal Corporation.