Potential cure for HIV discovered: Study

In a breakthrough that could potentially lead to a cure for HIV infection, scientists have discovered a way to remove the virus from infected cells, a study released on Friday said.

In a breakthrough that could potentially lead to a cure for HIV infection, scientists have discovered a way to remove the virus from infected cells, a study released on Friday said. The scientists engineered an enzyme which attacks the DNA of the HIV virus and cuts it out of the infected cell, says a study published in Science magazine.

The enzyme is still far from being ready to use as a cure, the authors warned, but it offers a glimmer of hope for the more than 40 million people infected worldwide.

8220;A customised enzyme that effectively excises integrated HIV-1 from infected cells in vitro might one day help to eradicate the virus from AIDS patients,8221; Alan Engelman, of Harvard University8217;s Dana-Farber Cancer Institute, wrote in an article accompanying the study.

Current treatments focus on suppressing the HIV virus to delay the onset of AIDS.

What makes HIV so deadly, however, is its ability to insert itself into the body8217;s cells and force those cells to produce new infection.

8220;Consequently, the virus becomes inextricably linked to the host, making it virtually impossible to 8216;cure8217; AIDS patients of their HIV-1 infection,8221; Engelman explained.

That could change if the enzyme developed by a group of German scientists can be made safe to use on people.

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That enzyme was able to eliminate the HIV virus from infected human cells in about three months in the lab.

The researchers engineered an enzyme called Tre which removes the virus from the genome of infected cells by recognising and then recombining the structure of the virus8217;s DNA.

This ability to recognise HIV8217;s DNA might one day help overcome one of the biggest obstacles to finding a cure: the ability of the HIV virus to avoid detection by reverting to a resting state within infected cells which then cease to produce the virus for months or even years.

Researchers were also optimistic about developing additional enzymes which would target other parts of the virus8217;s DNA.