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This is an archive article published on May 8, 2005

Mind that Inch Hand

OUR molecular body clock may also play a role in regulating appetite, researchers report, in a finding that could someday be used to help co...

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OUR molecular body clock may also play a role in regulating appetite, researchers report, in a finding that could someday be used to help compulsive eaters slim down.

Mice bred to have irregular body clocks were unable to keep their body weight under control, said the report in the April 21 online issue of Science by investigators at Northwestern University.

8216;8216;These animals have the munchies all day long and in actuality eat all night long as well,8221; said lead investigator Dr Joseph Bass, an assistant professor of medicine, neurobiology and physiology at Northwestern. Mice with normal body clocks eat just twice a day, he added.

One important finding is that 8216;8216;the clock, which we thought is only in the central part of the brain, is actually also present in the part of the brain that controls appetite,8217;8217; Bass said.

Biological clocks function not only in the brain, but in many parts of the body as well. They govern not only the sleep cycle but also functions including fluid balance, body temperature, oxygen consumption8212;and now, it has been shown, appetite, the researchers said.

8216;8216;This provides new genetic evidence that physiological outputs of the biological clock, sleep and appetite, are interconnected at the molecular and behavioural levels,8217;8217; said Fred W Turek, professor of neurobiology and physiology at Northwestern, and a member of the research team.

The finding could help develop new strategies 8216;8216;to reduce and sustain weight loss resulting from both medical and lifestyle modifications,8217;8217; he added.

NYT

 

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