CHENNAI, Jan 3: Dr N K Shanmugham, a siddha medical practioner, has developed a combination, Immunez, the clinical trails of which, among small group of HIV positive people, has shown a considerable reduction in the viral load and increase in CD4 counts in the infected persons. The drug worked as a very effective anti-retroviral (ARV) and was much more cost-effective than the ARVs marketed by the multi-national corporations.