Plasma therapy may not reduce mortality, suggests ICMR study

While use of convalescent plasma as a treatment modality for Covid-19 has received authorisation for off-label use in India, the aim of ICMR’s PLACID trial was to investigate its effectiveness for treatment of Covid-19.

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Convalescent plasma therapy uses blood from people who have recovered from an illness to help others recover. (File)

Convalescent Plasma was not associated with reduction in mortality or progression to severe Covid-19, suggests a study by Indian Council of Medical Research published in MedRxiv, a preprint server for health sciences. ICMR officials told The Indian Express that the study, published on September 8, has not been peer-reviewed and preferred not to comment.

While use of convalescent plasma as a treatment modality for Covid-19 has received authorisation for off-label use in India, the aim of ICMR’s PLACID trial was to investigate its effectiveness for treatment of Covid-19.

The PLACID trial results indicate that there was no difference in the 28-day mortality or progression to severe disease among moderately-ill Covid-19 patients treated with convalescent plasma along with basic standard care compared to basic standard care alone.

Explained: How effective is plasma therapy for Covid-19?

Convalescent plasma therapy uses blood from people who have recovered from an illness to help others recover. Blood donated by people who have recovered from Covid-19 has antibodies to the virus that causes it. The donated blood is processed to remove blood cells, leaving behind liquid (plasma) and antibodies. These can be given to people with Covid-19 to boost their ability to fight the virus.

ICMR’s plasma therapy study, PLACID, is the first and largest randomised control trial to be completed in the world and according to the study paper, two earlier studies from China and the Netherlands could not be completed.

Also Read | Health worker is Bengal’s 50th blood plasma donor, vows to return for more

The randomised controlled was registered with Clinical Trial Registry of India (CTRI) and conducted in 39 tertiary care hospitals across the country. Between April 22 and July 14, a total of 464 participants were enrolled—235 and 229 in the intervention and control arms, respectively.

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Mortality was documented in 34 (13.6%) and 31 (14.6%) participants in the intervention and control arm, respectively.

Convalescent plasma therapy has received regulatory approval for use in patients in different countries, leading to its wide adoption.

Anuradha Mascarenhas

Anuradha Mascarenhas is a Senior Editor at The Indian Express, based in Pune. With a career spanning three decades, she is one of the most respected voices in Indian journalism regarding healthcare, science and environment and research developments. She also takes a keen interest in covering women's issues . Anuradha has won several awards including the Press Council of India's national award for excellence in journalism under the gender based reporting category in 2019 and the Laadli Media award (gender sensitivity -2024). A recipient of the Lokmat journalism award (gender category-2022), she was also shortlisted for the RedInk awards for excellence in journalism-2021. Her debut book At The Wheel Of Research, an exclusive biography of Dr Soumya Swaminathan the inaugural chief scientist of World Health Organisation was also nominated in the Popular Choice Category of JK Paper AUTHER awards. She has also secured competitive fellowships including the Laadli Media Fellowship (2022), the Survivors Against TB – New Research in TB Media Fellowship (2023) and is part of the prestigious 2025 India Cohort of the WomenLift Health Leadership Journey.” Professional Background Education: A gold medalist in Communication and Journalism from Savitribai Phule Pune University and a Master’s degree in Literature. Author: She authored the biography At The Wheel Of Research, which chronicles the life and work of Dr. Soumya Swaminathan, the former Chief Scientist at the WHO. Key Focus: She combines scientific accuracy with storytelling, translating complex medical research into compelling public and human-interest narratives. Recent Notable Articles (Late 2025) 1. Cancer & Specialized Medical Care "Tata Memorial finds way to kill drug-resistant cancer cells" (Nov 26, 2025): Reporting on a breakthrough for triple-negative breast cancer, one of the most aggressive forms of the disease. ``Discipline, diet and purpose; How a 97-year-old professor defies ageing'' (Nov 15, 2025) Report about Prof Gururaj Mutalik, the first Head of Department at Pune's B J Government Medical College who at 97 credits his longevity to healthy habits and a strong sense of purpose. 2. Environmental Health (The "Breathless Pune" Series) "Long-term exposure even to 'moderate' air leads to chronic heart, lung, kidney issues" (Nov 26, 2025): Part of an investigative series highlighting that even "safe" pollution levels are damaging to vital organs. "For every 10 µg/m3 increase in PM2.5 level, there was 6-8% jump in medicine sales" (Nov 23, 2025): Using commercial data to prove the direct link between air quality and respiratory illnesses in Pune. 3. Lifestyle & Wellness News "They didn't let cancer, diabetes and heart disease stop them from travelling" (Dec 22, 2025): A collaborative piece featuring survivors who share practical tips for traveling with chronic conditions. ``At 17, his BP shot up to 200/120 mmHG; Lancet study flags why child and teen hypertension doubled between 2000 and 2020'' (Nov 12,2025)--A report that focusses on 17-year-old-boy's hypertensive crisis and reflects the rising global trend of high blood pressure among children and adolescents. 4. Scientific Recognition & Infrastructure "For promoting sci-comm, gender diversity: IUCAA woman prof highlighted in Nature" (Nov 25, 2025): Covering the global recognition of Indian women scientists in gender studies and physics. ``Pune researchers find a spiral galaxy like the Milky Way from early universe'' (December 3, 2025)- A report on how Indian researchers discovered a massive galaxy that existed when the universe was just 1.5 billion years old , one of the earliest to have been observed so far. Signature Beat: Health, Science & Women in Leadership Anuradha is known for her COVID-19 reportage, where she was one of the first journalists to provide detailed insights into the Covishield and Covaxin trials. She has a dedicated interest in gender diversity in health and science, often profiling women researchers who are breaking the "leaky pipeline" in STEM fields. Her writing style is scrupulous, often featuring interviews with top-tier scientists and health experts from various institutions X (Twitter): @runaanu ... Read More

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