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Journalism of Courage
How well your brain functions is largely based on your family’s genetic makeup,says a study.
An international team,led by University of Melbourne,has found that the efficacy of each person’s brain network is based on their genetic makeup,the ‘Journal of Neuroscience’ reported in its latest edition.
Lead author Dr Alex Fornito said the findings have important implications for understanding why some people are better able to perform certain tasks than others and genetic basis of mental illnesses and some neurological diseases.
He said how the brain’s network is organized has been a mystery to scientists for years. “The brain is an extraordinarily complex network of billions of nerve cells interconnected by trillions of fibres.
“The brain tries to maximise its bang-for-buck by striking a balance between making more connections to promote efficient communication and minimising the ‘cost’ or amount of wiring required to make these connections.
“Our findings indicate that this balance,called ‘cost-efficiency’,has a strong genetic basis,” he said.
According to researchers,the study could help uncover which specific genes are important in explaining differences in cognitive abilities,risk for mental illness and diseases such as schizophrenia and Alzheimer’s,leading to gene-based therapies for these disorders.
“Although genes play a major role in brain function,the environment and other factors contribute to when things go wrong in cases of mental illness and other brain disorders,” he said.
The research team,which included scientists at the Universities of Queensland and Cambridge,UK,compared the brain scans of 38 identical and 26 non-identical twins from the Australian Twin Registry.
Using new techniques,the researchers were able to construct detailed maps of each persons brain network and measured the cost-efficiency of network connections for the entire brain,as well as for specific brain regions.
“We found that people differed greatly in terms of how cost-efficient the functioning of their brain networks were,and that over half of these differences could be explained by genes,” said Dr Fornito.
Across the entire brain,more than half (60 per cent) of the differences between people could be explained by genes.
Some of the strongest effects were observed for regions of the prefrontal cortex that play a vital role in planning,memory,strategic thinking and decision-making.
“This exciting discovery opens up a whole new area of research focus for scientists around the world,” he said.
