‘My hair is fuller, my skin is better…I’m talking about sex’: Amy Schumer says weight loss drug Mounjaro alleviated perimenopausal symptoms; we check with a doctor

“I was puking—I couldn’t handle it,” she said, adding that she wasn’t sure if the formula had changed since then. After that, she switched gears and booked a telehealth appointment, where she was prescribed hormonal support—specifically estrogen and progesterone—to help with symptoms linked to perimenopause.

But what really stood out in her update was her mention of Mounjaro, a drug initially created for type 2 diabetes that’s now gaining attention for its weight-loss benefits. “Mounjaro’s been great,” Schumer said, noting that the mix of medications has left her feeling better overall. “My symptoms of being in perimenopause have disappeared. My hair is fuller, my skin is better, I have more energy. I want to ‘get down’ more, if you know what I mean,” she joked, quickly clarifying: “I’m talking about sex.”

So, can a drug like Mounjaro really help with symptoms related to perimenopause, or is the benefit more of a side effect?

Understanding Mounjaro’s role in the bigger picture

Dr Chetna Jain, director of obstetrics & gynaecology at Cloudnine Hospital in Gurgaon, says that while Mounjaro isn’t technically a hormone therapy, it might still support women dealing with some of the more stubborn aspects of perimenopause.

 

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“Mounjaro works by mimicking certain gut hormones that help manage things like blood sugar levels, appetite, and how your body responds to insulin,” explains Dr Jain. “During perimenopause, a lot of women experience increased insulin resistance, especially around the abdomen, due to declining estrogen.”

That’s where drugs like Mounjaro can come in—by improving how the body processes sugar and reducing inflammation, women may feel more energetic, sleep better, and even notice mood improvements.

So, is it the weight loss—or something more?

In Schumer’s case, she’s using a hormone combo and Mounjaro, so it’s likely the combination is helping her feel more like herself. While Mounjaro doesn’t directly affect estrogen levels, the indirect benefits—like shedding stubborn weight, easing fatigue, and stabilising blood sugar—can absolutely have a ripple effect.

“Many female patients report better energy and mood after using GLP-1 medications, even though the drugs aren’t technically treating their hormone issues,” says Dr Jain. “It’s about helping the body run more efficiently when everything feels out of balance.”

Things to consider before jumping in

Of course, just because it worked for Amy doesn’t mean it’s the right fit for everyone.

“These drugs aren’t for people with certain medical histories,” Dr Jain cautions. “Anyone with a personal or family history of medullary thyroid cancer, MEN2 syndrome, or pancreatitis should steer clear.” They’re also not recommended during pregnancy or for women actively trying to conceive.

And like many medications, they come with side effects. The more common ones include nausea, constipation, acid reflux, and in rare cases, pancreatitis or gallbladder issues.

“These drugs can help some women feel better, but they’re not a replacement for hormone therapy if that’s needed,” Dr Jain emphasizes. “It’s best to speak to your doctor about what combination works best for your body.”

DISCLAIMER: This article is based on information from the public domain and/or the experts we spoke to. Always consult your health practitioner before starting any routine.