Can you predict cancer risk seven years in advance with blood tests? Two studies have some answers

Decoding the findings, Dr Manish Singhal, senior consultant, medical oncology, Indraprastha Apollo Hospitals, New Delhi says while some proteins are shed from cancer cells, the human body generates cancer cells daily and destroys them too. “Therefore having a protein may not be a certainty of you developing cancer but a red flag that you need to switch over to a corrective lifestyle,” he adds.

How helpful can such blood tests on protein markers be in diagnosing various kinds of cancer in India? 

We need to see long-term results of such tests to be sure of their efficacy. Most existing treatments are based on solid proof of cancer on biopsy and CT scans. Imagine the fear and anxiety in a person who is told on the basis of protein markers that they could develop cancer in later years but would be treated only when the disease showed up on scans and biopsy. What if they never develop cancer but definitely slip into depression due to continued fear? A possibility should also be followed by a preventive guidance.

What are the potential links between plasma proteins and cancer risk?

There is a certain link that such proteins are shed by cancer cells. High protein levels could point to certain types of cancer (mostly blood cancers like leukemia, lymphoma and multiple myeloma). Some tests, like the comprehensive metabolic panel (CMP) test, include a total protein test by default, which can also provide this information.

If these proteins are found in a person, should they worry? 

We need to have clear and accepted  protocols of what to do with the result of such a test which I think is still lacking. We cannot leave the person in ambiguity after the result. This onus lies with the test makers.

How important is it to diagnose cancer early?

Certainly early diagnosis can save lives. That’s why such tests cannot afford to be just indicative but definitive. Besides, they need precise follow-up protocols.