Pig parasite may treat autoimmune disorders
BOSTON: If you had a chronic and potentially debilitating condition such as rheumatoid arthritis or Crohns disease,and swallowing the eggs of a pig parasite could help,would you do it? The team at Coronado Biosciences Inc is betting you would. The Burlington,Massachusetts,company is developing what it hopes will be the first in a new class of treatments for autoimmune conditions. Each dose of the drug consists of thousands of microscopic parasite eggs,culled from pig feces,suspended in a tablespoon of saline solution to be swallowed. In a pig,the eggs would grow into mature whipworms and reproduce,without harming their host. In humans,the same eggs barely survive two weeks. Yet in that short period they appear to modulate a patients immune system and prevent it from attacking the bodys own tissues and organs. The company is preparing to enroll 220 patients with Crohns disease in a midstage clinical trial.
Infant antibiotics linked with more weight
NEW YORK: Young farm animals given antibiotics gain weight quickly. Now a new study suggests that the same thing may happen to human infants treated with antibiotics. Researchers writing online last week in The International Journal of Obesity studied 11,532 English children born at normal weight in 1991 and 1992. Controlling for birth weight,parental body mass index,breast-feeding and other factors,they found that infants given antibiotics within six months of birth were 22 per cent more likely than those given none to be overweight at age three. Among those given antibiotics between 6 and 14 months,there was no link to body mass in childhood,but exposure from 15 to 23 months was linked to higher BMI at age seven. This study does not suggest that antibiotics are bad for you, said the lead author,Dr. Leonardo Trasande,an associate professor of pediatrics at New York University. But our findings add to concerns about the inappropriate use of antibiotics.