New method can diagnose osteoarthritis at early stage and prevent it

“Osteoarthritis often attacks the knee and hip joints and breaks down the impact absorbing cartilage found there,” said Carl Siversson,who has just defended his thesis in Medical Radiation Physics at Lund University in Sweden.

“For those affected,the progression of the disease usually takes many years,with gradually increasing pain which often leads to disability,” he said.

A few years ago,researchers from Lund University and Harvard Medical School developed a method to measure the degree of osteoarthritis using an MRI scanner,even at a very early stage. The method is called dGEMRIC (delayed gadolinium-enhanced MRI of cartilage).

“This was major progress,but one problem was that the measurements could only be performed in a limited part of the cartilage,” Siversson said.

“We have now improved the method so that we can study all the cartilage in the joint at once. We have achieved this by solving the problem of how to correct all the irregularities in the MRI images,” he said.

The improved method has now been tested both on healthy individuals and on individuals with osteoarthritis,and the results show that the disease can now be monitored in ways that were not previously possible.

“Now we are continuing our work to make the method easy for doctors to use in their practice,” said Siversson,who after completing his PhD will continue his research at Harvard Medical School in Boston,US.

“Our hope is that the method will also be significant for future drug development,” he added.