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This is an archive article published on February 26, 2010
Gene-based therapy may help treat HIV-infected individuals
Scientists have successfully removed CCR5 a cell receptor to which HIV-1 binds for infection but which the human body does not need from human cells.
Written by ANI
Washington | February 26, 2010 12:10 PM IST
1 min read
1 min read
Scientists have successfully removed CCR5 a cell receptor to which HIV-1 binds for infection but which the human body does not need from human cells.
Individuals who naturally lack the CCR5 receptor have been found to be essentially resistant to HIV.
Using a humanized mouse model,UCLA AIDS Institute researchers transplanted a small RNA molecule known as short hairpin RNA (shRNA),which induced RNA interference into human blood stem cells to inhibit the expression of CCR5 in human immune cells.
The findings provide evidence that this strategy can be an effective way to treat HIV-infected individuals,by prompting long-term and stable reduction of CCR5.
The study has been published in Blood,Journal of the American Society of Hematology.
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