Can Semaglutide control your drinking habit too? Know what a new study says

Researchers further tested if Semaglutide had a deterrent effect even after a “sobriety” period. So they deprived the rats of alcohol for nine days and then re-administered the drug. After this, they reintroduced the rats to alcohol to see if they would return to their drinking baseline. They didn’t. “We found that Semaglutide prevents relapse drinking, which is a huge problem in patients with AUD (alcohol use disorder). They abstain from alcohol, a white period, and then they start drinking more once they start. This is also seen in rodents. This is prevented by Semaglutide. We found that Semaglutide prevents the reward from alcohol, and this might be the mechanism contributing to the reduced alcohol intake observed,” said Prof Jerlhag.

Although this needs to be tested on humans, Dr Anoop Misra, Chairman, Fortis-C-DOC Centre of Excellence for Diabetes, Metabolic Diseases and Endocrinology, feels “this intriguing study reveals that in addition to suppressing appetite, Semaglutide also induces alterations in brain biochemistry, resulting in reduced alcohol consumption. Given that excessive alcohol consumption exacerbates liver and nerve damage in individuals with diabetes, the potential dual benefit of Semaglutide holds significant promise and warrants further investigation in human subjects, making it an area of great interest.”

According to Dr Subhash Kumar Wangnoo, Senior Consultant Endocrinologist and Diabetologist, Apollo Centre for Obesity, Diabetes and Endocrinology, Indraprastha Apollo Hospitals, the study opens up new possibilities for addressing alcohol-related disorders and improving the lives of individuals struggling with addiction. “By exploring the impact of Semaglutide on the brain’s reward system, researchers have uncovered a potential mechanism that may mitigate alcohol cravings and promote abstinence. The study’s findings highlight the interconnectedness of physical health, mental health and substance use disorders, and the importance of taking a holistic approach to healthcare. While further research is needed to validate and expand upon these initial findings, the potential implications are immense. Semaglutide could offer a new therapeutic avenue, providing hope for individuals battling alcohol addiction and offering healthcare providers an additional tool to combat the detrimental effects of excessive alcohol consumption. As we continue to unravel the complexities of addiction, it is crucial to explore innovative solutions and repurpose existing medications. The study on Semaglutide’s potential in reducing alcohol use is a significant step forward, demonstrating the power of interdisciplinary research and its potential to transform lives,” he says.