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This is an archive article published on September 19, 2018

Failed organ transplants: 60-year-old second kidney recipient dies

An official from the Directorate of Health Services, Maharashtra, said state government is monitoring the case and a report from the ZTCC will be sought soon.

(Representational) Singh was put on ventilator support after massive internal bleeding. (Representational)

A fortnight after multiple organ transplants — from a 59-year-old donor — in three recipients failed, leading to the death of a kidney recipient, in a rare case, the second recipient died in Jaslok Hospital on Tuesday morning.

A technical committee appointed by the Zonal Transplant Coordination Centre (ZTCC) is scheduled to meet on Wednesday to assess the medical records of the 59-year-old donor, both kidney and one liver recipients to assess what led to acute hyper rejection in the case.
“We are awaiting histopathology reports of the donated organs. There may be immunological factors behind the rejection,” said doctor Avinash Supe, who is chairing the committee.

An official from the Directorate of Health Services, Maharashtra, said state government is monitoring the case and a report from the ZTCC will be sought soon. On September 5, Godavari Singh (60) underwent a kidney transplant under nephrologist M M Bahadur in Jaslok hospital. She was one of the three recipients whose transplant failed. On September 6, after the kidney did not function in her body, the doctors removed the donated organ.

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Singh was put on ventilator support after massive internal bleeding. Last week, her platelet count had dropped to 3,000. The normal range is between 1.5 and 4.5 lakh. On Sunday, blood clotting was noted in her body and according to doctors, she passed away at 7.30 am on Tuesday. Declining to comment on the medical condition of the kidney recipient, an official from Jaslok hospital said: “We are awaiting the technical expert committee meet. After that we will be in a better position to comment.” A post-mortem examination has not been conducted.

The Kandivali resident was cremated on Tuesday evening. While the family hoped that she would recover for a second kidney transplant, Singh’s condition worsened on Monday. She had been undergoing dialysis for the past eight years and waiting for kidney donation for five years in the ZTCC’s waitlist.

Singh received a kidney from the 59-year-old person whose family agreed to donate both the kidneys and the liver following brain-stem death in P D Hinduja Hospital on September 4.  One kidney was transplanted in a 31-year-old Bhuleshwar resident at Hinduja hospital. The person had been undergoing dialysis for 14 years. The next day, the kidney was removed, as the recipient’s body rejected it. He died on September 7 after suffering from low platelet count, low blood pressure and blood loss.

Another patient, a 73-year-old woman, underwent liver transplantation in Global Hospital. According to doctors, that organ was also rejected and the liver had to be removed from the recipient’s body.  On September 7, she underwent another liver transplant. “Her condition is better. She is recuperating,” a doctor from Global hospital said.

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Such multiple organ rejections from a single donor are rare. Doctors who conducted the transplants said human leukocyte antigen test, mandatory before each transplant, was carried for the donor and the recipients along with tests like HIV, Hepatitis, and other infectious diseases. “It is possible that some infection might have gone undiagnosed,” Supe said. The report from the committee is slated to be submitted in 15 days.

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