Chili pepper ingredient could prevent weight gain

“Our group’s laboratory data revealed that dietary capsaicin suppresses high-fat-diet-induced obesity,” explained Vivek Krishnan, a graduate student from the University of Wyoming in the US.

“In our bodies, white fat cells store energy and brown fat cells serve as thermogenic (heat produced by burning fat) machinery to burn stored fat. Eating calorie-rich food and a lack of physical activity cause an imbalance in metabolism that leads to obesity,” Krishnan explained.

The researchers found that high-fat-diet obesity and dietary capsaicin — 0.01 percent of capsaicin in the total high fat diet — prevented high-fat-diet-induced weight gain in trials with wild type mice.

Dietary capsaicin may induce browning of white adipose tissue and stimulates thermogenesis to counteract obesity, the researchers noted.

Developing a natural dietary supplement as a strategy to combat obesity can be easily advanced to human clinical trials.

“We envision a nanoparticle-based sustained-release formulation of capsaicin, which is currently under development in our laboratory,” the researchers added.

“In turn, this will advance a novel dietary supplement-based approach to prevent and treat one of the life-threatening diseases, obesity and its associated complications — in humans,” they noted.

The findings were presented at Biophysical Society’s 59th annual meeting in Baltimore, Maryland.