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Journalism of Courage
The US Food and Drug Administration (FDA) recently approved Blujepa (gepotidacin), a ground-breaking oral antibiotic for treating uncomplicated urinary tract infections (UTIs). This is the first new oral antibiotic for UTIs in nearly 30 years, offering hope to millions of women who suffer from recurrent infections that are increasingly resistant to traditional treatments.
However, before we understand what the drug is, let me also emphasise that preventive care with hygiene and wash practices continues to be another pillar for women’s health.
A game-changing antibiotic
Blujepa, developed by GSK, is specifically designed to treat uncomplicated UTIs caused by bacteria such as E. coli. It is approved for women and girls aged 12 and older. What sets Blujepa apart is its innovative mechanism of action, which targets bacteria differently from older antibiotics like nitrofurantoin or trimethoprim-sulfamethoxazole. This helps reduce the likelihood of antimicrobial resistance (AMR), when bacteria evolve to resist the drugs designed to kill them, making infections harder to treat. That’s why this new antibiotic is a promising solution for those struggling with recurrent or treatment-resistant UTIs.
Hydration: A key preventive measure
Drinking sufficient water increases urination frequency, which helps flush bacteria out of the urinary tract before they can cause an infection. Research shows that increasing daily fluid intake by just 200-400 millilitres can significantly reduce UTI prevalence.
Proper hydration also dilutes urine, making it less conducive to bacterial growth. Frequent emptying reduces residual urine within the bladder where bacteria grow. Hydration is a simple drill.
1) Aim for six to eight glasses of water daily.
2) Avoid excessive consumption of alcohol or caffeinated beverages, which may irritate the bladder.
3) Monitor your urine color; light yellow or clear urine is a good indicator of adequate hydration.
Hygiene practices to prevent UTIs
Good hygiene habits are equally important in reducing UTI risk as women are particularly susceptible due to anatomical factors like a shorter urethra and its proximity to the anus, which makes it easier for bacteria like E. coli to enter the urinary tract.
Wipe Front to Back: Always wipe from front to back after using the toilet to prevent bacteria from spreading from the anus to the urethra.
Urinate Regularly: Avoid holding your urine for long periods; emptying your bladder every four hours reduces bacterial growth.
Wash Before and After Sexual Activity: Cleaning with soap and water before sex reduces bacterial transfer, while urinating afterward helps flush out any bacteria that may have entered the urethra.
Avoid Irritating Products: Steer clear of douches, scented sprays, or powders that can disrupt the natural balance of bacteria in the urinary tract.
Choose Breathable Fabrics: Opt for cotton underwear and avoid tight clothing that traps moisture and promotes bacterial growth.
Lifestyle adjustments can help prevent UTIs. While not a proven cure, cranberry products and D-mannose supplements may help prevent bacteria from adhering to the urinary tract lining. Try probiotics. For post-menopausal women, estrogen creams can restore vaginal pH balance and promote the “good” bacteria.
(Dr Suri is a gynaecologist at Apollo Hospitals, Delhi)
