Oct 21, 2025

Why is Alzheimer's common among females?

Aanya Mehta

Longer Life Expectancy

Women tend to live longer than men, and since age is the biggest risk factor for Alzheimer’s, this increased lifespan contributes to the higher prevalence of the disease among women.

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Brain Structure Differences

Studies have found that women have different brain structures and functions compared to men, which may influence the progression of Alzheimer’s. These differences could affect how the disease develops and progresses.

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Underdiagnosis of Women

Women are often diagnosed with Alzheimer’s at later stages, possibly due to differences in how symptoms manifest. This delay in diagnosis can affect treatment outcomes.

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Hormonal Differences

Oestrogen has neuroprotective effects, and its decline during menopause may increase the risk of Alzheimer’s. Some studies suggest that early menopause may further elevate this risk.

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Genetic Factors

The APOE-e4 gene variant is associated with an increased risk of Alzheimer’s. Research indicates that women with this gene variant may have a higher risk compared to men.

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Impact of Menopause Symptoms

Experiencing hot flashes, especially at night, during menopause may be linked to a higher risk of developing Alzheimer’s. These symptoms could be indicative of changes in brain health.

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Prevention and Awareness

While some risk factors are beyond control, maintaining a healthy lifestyle, staying mentally and socially active, and managing cardiovascular health can help reduce the risk of Alzheimer’s. Early detection and awareness are key in managing the disease.

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Primary Caregivers

Women are more likely to be primary caregivers for individuals with Alzheimer’s, which may influence their own risk factors and the progression of the disease.

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