Dark knuckles can be a symptom of a variety of health conditions as well as be caused due to vitamin deficiency and certain drugs.
Acanthosis nigricans (AN)
It is a condition that involves the darkening and thickening of the skin in one or more areas of the body.
Prediabetes and diabetes
Darkening knuckles can signify the onset of diabetes. It’s believed that high levels of insulin may affect the growth of skin cells.
Vitamin B-12 deficiency
According to a 2016 study, dark knuckles can be an important sign of vitamin B-12 deficiency. When the deficiency is treated, the skin of the knuckles is likely to return to their normal colour.
Dermatomyositis
It is a rare inflammatory disease that can cause muscle weakness and a skin rash. This rash can be bluish-purple and appear anywhere on the body, including the knuckles.
Addison’s disease
This rare condition can lead to fatigue and darkening in skin colour. The darker skin tends to appear near scars or skin creases like the knuckles.
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