Nick Kyrgios is Australia's highest-ranked player in the men's draw, but Alexander Zverev was blunt when asked about the prospect of the 23rd seed ending the host nation's 42-year wait for a homegrown singles champion.
Several of those who played on Tuesday and Wednesday suffered breathing problems, with Slovenia's Dalila Jakupovic forced to retire after a coughing fit.
Prajnesh Gunneswaran failed to make the main draw of the Australian Open men's singles event after going down in straight sets to Ernests Gulbis of Latvia in the final round of the qualifiers on Friday.
Sania Mirza and her Ukrainian partner Nadiia Kichenok stormed into the women's doubles final of the Hobart International with a straight-set win.
Alex de Minaur, who was also forced to pull out of this week's Adelaide International, said he had suffered a "four-centimeter Grade 2" abdominal tear representing his country at the ATP Cup.
Caroline Wozniacki will take her final bow over the next fortnight at Melbourne Park, the scene of her only Grand Slam victory in a career that earned her praise for her tenacity and approachable character but also saw her acquire detractors.
Sania and Kichenok made a strong start and broke their opponents twice to take the lead. They also did well to save four break points in the opening set.
Tournament organizers faced criticism this week for going ahead with qualifying rounds, as smoky conditions forced a player to retire after a coughing fit.
The lone Indian contender in women's singles qualifier, Anikta Raina also made an early exit after losing 6-2 7-6 against Bulgaria's Viktoriya Tomova.
Canada's Brayden Schnur took aim at 20-times Grand Slam champion Roger Federer and world number one Rafael Nadal for not taking a vocal stand for the lower-profile players in qualifying.
The 22-year-old Indian was scheduled to take on Egypt's Mohamed Safwat in the first round of the qualifiers, but smoke from bushfires that are blanketing Melbourne played spoilsport.
Roger Federer continues to defy the ageing process but even the great Swiss will know the window of opportunity to add to his Grand Slam haul is growing narrower every passing month.
Angelique Kerber, who won the Australian Open in 2016, had on-court medical help for her lower back injury and then retired in her match against Dayana Yastremska.
A Slovenian player suffers a coughing fit as smoke, poor air quality blight Aus Open qualifying event.
While Prajnesh Gunneswaran will face Germany's Yannick Hanfmann in the second-round, Sumit Nagal will open his campaign in the qualifiers against Egypt's Mohamed Safwat on Wednesday.
Slovenia's Dalila Jakupovic was leading Stefanie Vogele at Melbourne Park when she slumped to her knees at the back of the blue hardcourt suffering breathing difficulties because of the bushfire smoke.
Returning to the court after two years, Sania Mirza and Ukrainian partner Nadia Kichenok prevailed 2-6, 7-6 (3), 10-3 over Oksana Kalashnikova of Georgia and Japan's Miyu Kato in a contest lasting one hour and 41 minutes.
Novak Djokovic recorded a ninth consecutive hard-court win over world number one Rafael Nadal on Sunday as Serbia were crowned champions at the inaugural ATP Cup team event.
With the final locked at 1-1 after the singles were shared, Novak Djokovic partnered veteran Victor Troicki to beat Spain's Pablo Carreno Busta and Feliciano Lopez 6-3, 6-4 and win the title.
Sania Mirza and her partner Nadiia Kichenok have been drawn to meet Oksana Kalashnikova of Georgia and Miyu Kato of Japan in their opening round at the Hobart International.