Forward Leo Baptistao sent two point-blank shots over the bar and Gerard Moreno had a goal waived off for a questionable foul.
Lionel Messi faces one of his favourite opponents in Atletico Madrid as Barcelona look to extend their 100 percent start to the league season.
Zinedine Zidane said he does not know when Gareth Bale will return from his latest calf problem.
Barcelona played their last match behind closed doors as the October 1 referendum, deemed illegal by the Spanish government, took place amid chaotic scenes.
It will be the first time Barcelona have visited the capital since a disputed referendum on independence in Catalonia which has stoked tensions with the Spanish government.
Catalan sports minister Gerard Figueras last week said Barcelona may be able to play in another country should the region achieve independence from Spain.
Espanyol and Girona, also based in Catalonia, released statements on Monday declaring their intentions to join the general strike as well.
Barcelona beat Las Palmas 3-0 in an empty Nou Camp stadium on Sunday afternoon, after club president Josep Maria Bartomeu decided to play behind closed doors.
Real Madrid beat Catalan club Espanyol 2-0 with a pair of goals by Isco in a match in which Madrid fans displayed cards with the Spanish flag colors.
The Catalan Football Federation (FCF) had already cancelled all games in the fourth tier and regional and amateur games.
Atletico Madrid's three-game winning streak in La Liga was halted by a goalless draw at Leganes which dropped them to third in the standings.
Girona quickly went ahead on goals by Cristian Portugues and Christian Stuani, before Maxi Gomez made it 2-2 for the hosts in the 16th minute.
Muniain tore a ligament in his other knee in April 2015, knocking him out of competition for nearly a year.
The Nou Camp has witnessed displays of pro-secession fervour in recent years, including chants of "independence" which take place after 17 minutes and 14 seconds in a match to mark the 1714 siege of Barcelona.
Diego Costa's return to La Liga side Atletico Madrid from January 1, 2018 has been finialised, Premier League champions Chelsea.
Manolo Marquez quits after a 2-0 loss to Leganes on Sunday left Las Palmas with six points from six games. The team next faces Barcelona on Sunday.
Antonio Sanabria, who scored the injury-time winner against Madrid at Santiago Bernabeu Stadium last week, netted a goal in each half against Levante.
Simone Zaza added to his scoring streak with a late goal that gave unbeaten Valencia a 3-2 win at Real Sociedad in a thrilling La Liga match.
Marcelino pulled a thigh muscle in his left leg while celebrating Simone Zaza's 85th-minute winner at Anoeta Stadium.
Barcelona was helped by two own goals from Girona as it eased to a 3-0 win and kept its perfect record in the Spanish league.
Real Madrid has gotten off to a slow start after two draws and a loss in three home matches. With only two wins from five matches, it is seven points behind leader Barcelona.
A spectacular volley by defender Jose Manuel Chema Rodriguez led Levante over Real Sociedad 3-0 in the Spanish league.
Things have changed quickly in favor of the low-key, hard-working Brazilian. Paulinho has two goals, including a late winner against Getafe last weekend, and showed some of the prowess that led him to success in Brazil and made him an indisputable starter for his national team.
A crisis over Catalonia's latest push for independence came to a head this week as Spanish police raided Catalan government offices and arrested officials to halt the referendum on Oct. 1, sparking mass protests in Barcelona and several other Catalan cities.



