"It's over when it's over, not before," said Jurgen Klopp, who is now purely focused in Liverpool's next games at Shrewsbury Town in the FA Cup and West Ham United in the Premier League.
After Raul Jimenez's second-half header cancelled out Jordan Henderson's opener, Roberto Firmino came up with the goods in the 84th minute to hand Liverpool a 14th consecutive league win.
Manchester United's Champions League qualification hopes suffered a blow with a 2-0 upset at home to Burnley. Meanwhile, Leicester cemented the third spot in the Premier League.
Newcastle United manager Steve Bruce described it as a wacky night of Premier League action after his side, and Arsenal salvaged unlikely 2-2 draws and Aston Villa grabbed a priceless last-gasp victory at Watford on Tuesday.
Virgil van Dijk and Mohamed Salah scored to give Liverpool a 2-0 victory over Manchester United at Anfield that sent Juergen Klopp's side 16 points clear at the top of the Premier League.
Skipper Deeney stepped up to take the spot-kick in the 69th minute after Jan Vertonghen handled Gerard Deulofeu's shot, but his effort was saved by Spurs keeper Paulo Gazzaniga.
Premier League referees are being instructed by the PGMOL, the body responsible for elite match officials in the English game, to make more use of pitchside monitors for red card decisions.
Manchester United are the only club to take points off runaway leaders Liverpool in the Premier League this season and they will try and do so again in Sunday's match at Anfield.
Sergio Aguero became the most prolific foreign goalscorer in Premier League history with a record-breaking hat-trick as Manchester City thrashed Aston Villa 6-1 to reclaim second place.
With closest rivals Leicester City suffering a shock 2-1 home defeat by Southampton, Roberto Firmino's goal sent Juergen Klopp's side 16 points clear at the top with a game in hand.
Even after dominating the first half, Mikel Arteta's new-look Arsenal faltered to keep their foot on the pedal as they slumped to an equaliser from Crystal Palace in the second half.
Oli McBurnie's goal earned Sheffield United a 1-0 home win over West Ham United but they needed a stoppage-time VAR intervention to secure the points that moved them to fifth place in the Premier League.
Tottenham will be without leading striker Harry Kane for the visit of Liverpool who have won 19 and drawn one of their 20 league games so far and lead the table by 13 points.
Danny Drinkwater, who won the league with outsiders Leicester City in 2016 and moved to Chelsea in 2017, spent the first half of the season on loan to Burnley after becoming surplus to requirements at Stamford Bridge.
Mohamed Salah scored one goal and set up the other as Liverpool extended its unbeaten Premier League run to a full year with a 2-0 victory over Sheffield United to restore its 13-point lead.
Arsenal showed signs they can excel under coach Mikel Arteta with an impressive 2-0 win at home to Manchester United in the Premier League on Wednesday while Southampton sunk Tottenham Hotspur 1-0 and Chelsea were held 1-1 at Brighton & Hove Albion.
Substitute Jahanbakhsh produced a goal for the highlight reels with six minutes left on the clock, with a superb overhead kick that flew into the bottom corner giving Chelsea goalkeeper Kepa Arrizabalaga no chance.
The video assistant referee (VAR) system was back in the spotlight on Sunday after drawing the ire from several managers during the Gameweek 20.
West Ham United have reappointed David Moyes as head coach on an 18-month deal to replace the sacked Manuel Pellegrini.
Arsenal's new manager Mikel Arteta said his team let themselves down with poor split-second decision-making in their 2-1 defeat by Chelsea in his first home game in charge on Sunday.