European explorers spread drug-resistant Tuberculosis to Asia: studyhttps://indianexpress.com/article/world/european-explorers-spread-drug-resistant-tuberculosis-tb-to-asia-study-5409462/

European explorers spread drug-resistant Tuberculosis to Asia: study

TB takes more lives than any other infectious disease and while its global burden has slowly declined over the past decade, the rise of antibiotic resistance (ABR) presents a major obstacle to its control, said researchers from University College London in the UK.

European explorers spread drug-resistant Tuberculosis TB to Asia: Study
TB takes more lives than any other infectious disease. (Source: Thinkstock)

The most common form of Mycobacterium tuberculosis (TB) originated in Europe and spread to Asia, Africa and the Americas with European explorers and colonialists, a study has found.

TB takes more lives than any other infectious disease and while its global burden has slowly declined over the past decade, the rise of antibiotic resistance (ABR) presents a major obstacle to its control, said researchers from University College London in the UK.

The study, published in the journal Science Advances, is the most thorough genomic analysis to date of the most widespread form of TB, called Lineage 4 TB, and significantly adds to our understanding of the origin and subsequent spread of the most common form of TB.

The team also mapped the evolution of drug resistant strains to investigate the mechanisms of ABR and found that drug resistant strains of Lineage 4 TB have hardly spread beyond the country in which they originated more recently.

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“Our findings strongly suggest that at least for Lineage 4, antibiotic resistance is a local challenge present in multiple countries and regions, but with minimal spread between them,” said Vegard Eldholm from Norwegian Institute of Public Health.

“Therefore, countries that succeed in halting transmission of resistant strains within their territory should expect to see a massive decrease of drug resistant TB,” Eldholm said.

“This is not to say that we should not be worried about the international spread of resistant strains, as these patterns might well change in the future, especially if the burden of antibiotic resistance keeps growing,” Eldholm said.

The researchers analysed genome sequences of 1,669 samples of Lineage 4 TB taken at different points in time from Europe, Africa, Southeast Asia, South America and North America.

These include samples taken from mummies hundreds of years old up to present day.

Each TB strain was positioned on a genetic family tree and its location was mapped geographically over time.

Of the seven lineage of TB, only Lineages 2 and 4 are truly global in their distribution, probably reflecting a combination of past human migrations and their more effective transmission relative to the other lineages.

Earlier studies have shown that the ancestor of all lineages of TB evolved in Africa 4000-6000 years ago and dispersed out of the continent to the rest of the world.

The new results demonstrate that Lineage 4 subsequently emerged in Europe around one thousand years ago before becoming the globally dominant form of TB.

They show that the earliest introductions of Lineage 4 into Africa happened in the Republic of Congo in the 15th century before spreading across the continent into South Africa, Uganda and Malawi in the late 17th century.

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This closely mirrors the European colonial history in Africa south of the Sahara with early Portuguese forts and trading posts established on the Gold Coast (present-day Ghana) in 1482, which was followed by European colonial expansion and internal African migration.