April 13, 2010 2:12:41 am
In a significant breakthrough with the potential for helping bio-pharmaceutical sector in the country,scientists at the Project Directorate on Poultry (PDP),Hyderabad,have mastered a technology to develop transgenic chickens by using the spermatozoa collected from the males of a layer chicken as a vehicle for transferring enhanced green fluorescent protein (EGFP) gene of jellyfish.
A team of scientists headed by T K Bhattacharya has developed the first transgenic chickens in the country,but the technology was earlier developed in the US,Canada,UK and China.
In the process which involved hatching of 263 chicks,the scientists,working on this project for the past two years,used universal promoter with green fluorescent protein vector modified for better expression of EGFP gene in the recipient cells.
After the experiment,16 of the 263 chicks demonstrated EGFP,indicating successful development of transgenic chicken. This means the scientists have managed to standardise the transgenic chicken development with an efficiency of 6 per cent.
The development is a major breakthrough in standardising the technology for developing transgenic chicken which can now be commercially exploited by the bio-pharmaceutical sector. We will apply for a patent soon, Bhattacharya told The Indian Express over the phone from Hyderabad.
He underlined the tremendous potential this technology has for bio-pharmaceutical sector. See,transgenic chicken can be used as a factory to produce biologically important proteins and peptides as the desired genes transferred to the chicken can be later isolated from the transgenic chicken in large quantity for medicinal purposes, he added.
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