scorecardresearch
Tuesday, Sep 27, 2022

What causes schizophrenia, scientists reveal

Scientists have produced the strongest yet evidence of what causes schizophrenia.

schizophrenia-main The symptoms of schizophrenia can be extremely disruptive, and have a large impact on a person’s ability to carry out everyday tasks (Source: Thinkstock Images)

Scientists have produced the strongest yet evidence of what causes schizophrenia.

An international team of scientists led by Cardiff University researchers discovered disease-linked mutations disrupt specific sets of genes contributing to excitatory and inhibitory signalling, the balance of which plays a crucial role in healthy brain development and function.

Lead author Dr Andrew Pocklington said that their study marks a significant step towards understanding the biology underpinning schizophrenia, which is an incredibly complex condition and had up until very recently kept scientists largely mystified as to its origins.

It would help them to develop a coherent model of the disease, while helping us to rule out some of the alternatives.

Subscriber Only Stories
Kurmi club: On national path, Nitish looks east, at UP’s Sonelal Pa...Premium
Interview: MD-CEO, Central bank of India | ‘During PCA years, none of our...Premium
The Kurmis: a political historyPremium
Deepti Sharma and the question of law vs spirit in cricketPremium
Schizophrenia-canva Presence of two or more of the following symptoms for at least 30 days (Source: helpguide.org)

“A reliable model of disease is urgently needed to direct future efforts in developing new treatments, which haven’t really improved a great deal since the 1970s.”

The paper not only confirms their previous findings, but also provides the first strong genetic evidence that disruption of inhibitory signalling contributes to the disorder.

The symptoms of schizophrenia can be extremely disruptive, and have a large impact on a person’s ability to carry out everyday tasks, such as going to work, maintaining relationships and caring for themselves or others.

The study is published today in the journal Neuron.

First published on: 05-06-2015 at 01:45:59 pm
Next Story

Cyber attack hits millions of U.S. federal workers, probe focuses on China

Latest Comment
Post Comment
Read Comments
Advertisement
Advertisement
Advertisement
Advertisement