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Japanese researchers are on the cusp of a dental revolution (Source: Freepik)
Imagine a world where tooth loss is no longer a permanent condition. Thanks to an innovative drug, that future may be closer than we think.
Japanese researchers are on the cusp of a dental revolution. After years of promising results in animal studies with mice and ferrets, they’re finally ready to test a groundbreaking drug that could potentially regrow adult human teeth.
Dentist Dr Niyati Arora explained that the entire study revolves majorly around one gene: USAG -1 (Uterine sensitisation associated gene). “USAG-1 controls the number of teeth to be formed in an individual by inhibiting the development of potential tooth germs. So, using something that inhibits this action of the gene, like an Anti-USAG 1 antibody, can be a remarkable step towards teeth regeneration,” Dr Arora explained.
By neutralising this protein, researchers believe they can stimulate the development of new teeth, offering a potential solution for millions of people who suffer from tooth loss.
The invention also gives hope to people who have lost one or more of their teeth as it would provide the option of a non-invasive procedure. (Source: Freepik)
The first phase of human trials will take place at Kyoto University and Kitano Hospital in Japan. Thirty adult men between the ages of 30 and 64, each missing at least one molar, will participate. The trial will last 11 months, and then the researchers intend to expand it to include children with congenital tooth deficiencies and older adults in subsequent phases.
Dr Arora said that if the trials becomes successful, they will solve the biggest challenge for children who suffer from anodontia, which is a condition where some or all of the teeth are missing since birth. For now, the only solution to this condition are dentures or implants.
The invention also gives hope to people who have lost one or more of their teeth as it would provide the option of a non-invasive procedure. “It would improve the quality of life of many individuals. It could possibly reduce the long-term costs added with dental treatments,” said Dr Arora in an interaction.
Not only this, it could lead to potential breakthroughs in the field of research and innovation and help in advancements in regenerative medicines and stem cell research.
While the drug holds immense promise and has been under development since 2005, it could take several years before it becomes available for general use. However, if all goes to plan, it could revolutionise dental care as soon as 2023 and provide a long-awaited option for people who have lost teeth.
DISCLAIMER: This article is based on information from the public domain and/or the experts we spoke to. Always consult your health practitioner before starting any routine.