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Simple urine test may predict biological age, death

In the new study, published in the journal in Frontiers in Aging Neuroscience, the team measured 8-oxoGsn in urine samples from 1,228 Chinese residents aged 2-90 years old.

urine test, predict biological age, death, urine test procedure, indian express, indian express news The urine test could help predict our risk of developing age-related disease, and even our risk of death. (Source: File Photo)

A simple urine test may determine how much people are getting older biologically, an advance that could help predict the risk of developing age-related disease and even death.

The findings showed that a substance indicating oxidative damage increases in urine as people get older.

This new marker potentially provides a method to measure how much our body has aged — our biological rather than chronological age.

While everyone born in the same year has the same chronological age, the bodies of different people age at different rates.

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The urine test could help predict our risk of developing age-related disease, and even our risk of death, the researchers said.

“Oxygen by-products produced during normal metabolism can cause oxidative damage to biomolecules in cells, such as DNA and RNA,” said Jian-Ping Cai, from Beijing Hospital.

“As we age, we suffer increasing oxidative damage, and so the levels of oxidative markers increase in our body,” Cai said.

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One marker, called as 8-oxo-7,8-dihydroguanosine — or 8-oxoGsn for short — results from oxidation of a crucial molecule — oxygen — in our cells called RNA.

Previous studies showed that 8-oxoGsn levels increase in urine with age in animals.

In the new study, published in the journal in Frontiers in Aging Neuroscience, the team measured 8-oxoGsn in urine samples from 1,228 Chinese residents aged 2-90 years old.

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“We found an age-dependent increase in urinary 8-oxoGsn in participants 21-year-old and older,” Cai said.

“Urinary 8-oxoGsn may reflect the real condition of our bodies better than our chronological age, and may help us to predict the risk of age-related diseases,” Cai said.

Interestingly, levels of 8-oxoGsn were found roughly the same between men and women, except in post-menopausal women, who showed higher levels.

This may have been caused by the decrease in estrogen levels that happens during menopause, as estrogen is known to have anti-oxidant effects, the researchers said.

First published on: 28-02-2018 at 02:30:25 pm
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