Follow Us:
Monday, August 15, 2022

Why dieting may not help you to lose weight?

When we eat less, our body compensates and burns fewer calories, which makes losing weight harder.

By: IANS | London |
May 24, 2017 10:20:37 pm
health, health and women, health survey, diet in india, effects of dieting, dieting medicine, dieting risk, healthy lifestyle, indian express, indian express news Dieting may not have good effects later. (Source: ThinkStock Images)

Looking to shed those extra kilos through dieting? You may be at a loss, as human bodies tend to compensate by sparing energy, limiting the number of calories that we burn and hence affect our weight loss regimen, researchers say.

According to the study, a group of neurons — agouti-related neuropeptide (AGRP) — in a brain region hypothalamus contributes to the caloric thermostat that regulates our weight, regulating how many calories we burn.

ALSO READ | Change eating schedule to lose your weight

When activated, these neurons make us hungry and drive us to eat, but when there is no food available, they tend to compensate for the reduction in calories.

Subscriber Only Stories
UPSC Essentials: Key terms of the past week with MCQsPremium
ExplainSpeaking | India at 75: 11 charts to understand how far India has ...Premium
Why a majority of Muslims opposed Jinnah’s idea of Partition and stayed o...Premium
Delhi Confidential: Who will hoist the Tricolour at the AICC headquarters...Premium

“Our findings suggest that AGRP in the brain coordinate appetite and energy expenditure, and can turn a switch on and off to burn or spare calories depending on what’s available in the environment,” said Clemence Blouet from the University of Cambridge in Britain.

“When we eat less, our body compensates and burns fewer calories, which makes losing weight harder,” Blouet added.

However, as soon as food becomes available and we start eating, the action of the AGRP neurons is interrupted and our energy expenditure goes back up again to normal levels.

In the study, published in the journal eLife, the researchers identified a new mechanism through which the body adapts to low caloric intake and limits weight loss in mice.


Using a genetic trick to switch the AGRP neurons on and off, they rapidly and reversibly manipulated the neurons’ activity in mice, a finding that could help in the design of new or improved therapies in future to help reduce overeating and obesity, the researchers said.

📣 The above article is for information purposes only and is not intended to be a substitute for professional medical advice. Always seek the guidance of your doctor or other qualified health professional for any questions you may have regarding your health or a medical condition.

For all the latest Lifestyle News, download Indian Express App.

  • Newsguard
  • The Indian Express website has been rated GREEN for its credibility and trustworthiness by Newsguard, a global service that rates news sources for their journalistic standards.
  • Newsguard
First published on: 24-05-2017 at 10:20:37 pm

Featured Stories