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Gastric medications may up risk for bacterial infection

It may be reasonable to re-evaluate the need for these medications in patients with C-diff.

gastric medication, bacterial infection, gastric acid, healthy bacteria, gastric problems, gastric problem solutions, health, lifestyle, indian express, indian express news Infections by C-diff are caused by disruption of normal, healthy bacteria in the colon. (Source: Thinkstock Images)

People using gastric acid suppression medications may be at a higher risk of bacterium infection that can cause diseases ranging from diarrhoea to life-threatening colon inflammation, researchers, including one of Indian-origin, warned.

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Infections by Clostridium difficile colitis (C-diff) are caused by disruption of normal, healthy bacteria in the colon, often as a result of antibiotics.

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The findings suggest that patients who previously had a case of C-diff and receive gastric acid suppressants may be at increased risk of C-diff recurrence.

“The study found that use of gastric acid suppression medications are associated with a statistically significant increased risk of development of recurrent C-diff in patients with a prior episode of C-diff,” said Sahil Khanna, a gastroenterologist at US-based non-profit Mayo Clinic.

For the study, published in JAMA Internal Medicine, the team conducted a systematic review and meta-analysis of 16 studies with 7,703 patients with C-diff and 1,525 of these developed recurrent C-diff.


The researchers analysed gastric suppression medications including proton pump inhibitors, such as omeprazole, and histamine 2 blockers, such as ranitidine, which are commonly prescribed and consumed over-the-counter medications for gastroesophageal reflux disease, peptic ulcer disease or dyspepsia.

The results showed that the rate of recurrent C-diff in patients with gastric suppression was 22.1 per cent, compared to 17.3 per cent in patients without gastric acid suppression.

Thus, “it may be reasonable to re-evaluate the need for these medications in patients with C-diff,” Khanna noted.

First published on: 28-03-2017 at 04:20:27 pm
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