Chronic stress ups risk of developing dementia, depression: Study

Chronic stress ups risk of developing dementia, depression: Study

Chronic stress — which is a pathological state — mimics response to fear and anxiety in brain scans, and can have harmful effects in the long-term.

chronic stress, pathology, fear, anxiety, depression, dementia, immune system, metabolic system, cardiovascular systems, hippocampus, long-term memory, spatial navigation, atrophy, neuroimaging, neurocircuitry, amygdala, medial prefrontal cortex, prefrontal cortex, PFC, neuropsychiatry, neuropsychiatric disorders, Alzheimer's disease, hippocampal neurogenesis, antidepressants, American Journal of Geriatric Psychiatry, geriatric psychiatry
Don’t brush off chronic stress as a normal part of modern, fast-paced life. It can snowball into major depression, and even dementia. (Source: Thinkstock Images)

People who suffer from chronic stress and anxiety may be at an increased risk for developing depression — and even dementia — a new study suggests.

Experiencing anxiety, fear and stress is considered a normal part of life when it is occasional and temporary — such as feeling anxious and stressed before an exam or a job interview.

However, when those acute emotional reactions become more frequent or chronic, they can significantly interfere with daily living activities such as work, school and relationships, according to researchers at Rotman Research Institute at Baycrest Health Sciences in Canada.

Chronic stress is a pathological state that is caused by prolonged activation of the normal acute physiological stress response, which can wreak havoc on immune, metabolic and cardiovascular systems, and lead to atrophy of the brain’s hippocampus — which is crucial for long-term memory and spatial navigation.


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Researchers examined recent evidence from studies of stress and fear conditioning in animal models, and neuroimaging studies of stress and anxiety in healthy individuals and in clinical populations. They looked specifically at key structures in the neurocircuitry of fear and anxiety — amygdala, medial prefrontal cortex and hippocampus — which are impacted during exposure to chronic stress.

The researchers noted similar patterns of abnormal brain activity with fear/anxiety and chronic stress — specifically an overactive amygdala (associated with emotional responses) and an under-active PFC (thinking areas of the brain that help regulate emotional responses through cognitive appraisal). The findings showed that there is an ‘extensive overlap’ of the brain’s neurocircuitry in all three conditions.

“Pathological anxiety and chronic stress are associated with structural degeneration and impaired functioning of the hippocampus and the prefrontal cortex (PFC), which may account for the increased risk of developing neuropsychiatric disorders, including depression and dementia,” said Linda Mah from Baycrest’s Rotman Research Institute.

“Antidepressant treatment and physical activity have both been found to increase hippocampal neurogenesis,” she said.

The findings were published in the American Journal of Geriatric Psychiatry.