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Cancer drugs can also battle antibiotic resistance

Researchers find proteins which cause antibiotic resistance similar to those vital for cancer.

Written by Agencies | Washington |
December 26, 2011 11:51:44 am

A new study has found that life saving drugs for cancer can also battle antibiotic resistance!

Researchers led by Gerry Wright,scientific director of the Michael G DeGroote Institute for Infectious Disease Research at McMaster University found that certain proteins which cause antibiotic resistance are structurally related to proteins vital in cancer.

“Our study found that certain proteins,called kinases,that confer antibiotic resistance are structurally related to proteins important in cancer”,said Wright.

“The pharmaceutical sector has made a big investment in targeting these proteins,so there are a lot of compounds and drugs out there that,although they were designed to overcome cancer,they can in fact be looked at with fresh eyes and maybe repurposed to address the problem of antibiotic resistance”,he said.

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The large-scale study involved screening 14 antibiotic resistant molecules against 80 chemically diverse protein kinase inhibitors.

Antibiotic resistance is a problem growing in global scope,as more viruses have overcome currently available antibiotics. “As a result,new drugs and antibiotic strategies are urgently needed to fill the gap in infectious disease control,” Wright stated.

Wright also said that he hopes future studies in combination therapies will provide new insight into antibiotic resistance. “One of the challenges facing the drug discovery community is the lack of new chemical scaffolds with antibiotic activity,” he said.


“This has led to the open question of whether all easily implementable antibiotic chemical scaffolds have already been exploited over the last 50 years: the so-called low hanging fruit“,he added.

The study has been published in Chemistry and Biology

📣 The above article is for information purposes only and is not intended to be a substitute for professional medical advice. Always seek the guidance of your doctor or other qualified health professional for any questions you may have regarding your health or a medical condition.

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First published on: 26-12-2011 at 11:51:44 am

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