September 27, 2016 10:55:59 pm
Diluted Manuka honey may be powerful remedy against growth of bacterial biofilms i medical devices, and may be use to reduce the risk o infections in hospital patients, a new study has found. Manuka honey is a monofloral honey produced in Australi and New Zealand from the nectar of the manuka tree.
According to the research by University of Southampton i the UK, even low dilutions of Manuka honey can curb th activity and growth of bacterial biofilms – the thin bu resilient layer of microbes.
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The research raise the prospect of the honey’s potentia use in patients fitted with medical devices, such as urinar catheters, which carry a high infection risk.
Around 100 million urinary catheters, used to drain th bladder of urine, are sold worldwide every year.
Up to one in four hospital patients may have to use catheter. However, long-term use is associated with frequen complications, such as inflammation and infection.
“We have been able to demonstrate that diluted honey i potentially a useful agent for reducing biofilm formation o indwelling plastic devices such as urinary catheters,” sai Bashir Lwaleed, associate professor at the University o Southampton, who led the study.
“Catheter infection rates can account for a larg proportion of hospital acquired infections – it is an area o clinical practice that needs addressing,” he added.
“We believe that patients might also benefit from honey’ anti-inflammatory properties, which are generally stronger i dark honeys, such as Manuka and that antibacterial resistanc is unlikely to be a factor when honey is used,” he said.
To find out if Manuka honey has a role in stopping th establishment and development of biofilms, the researcher cultured strains of Escherichia coli and Proteus mirabili bacteria on plastic plates in the laboratory.
These two bacteria account for most of the urinary trac infections associated with long-term catheter use.
The honey was diluted with distilled water and added t medium to give different ‘strengths’, 3.3 per cent, 6.6 pe cent, 10 per cent, 13.3 per cent, and 16.7 per cent.
In the first part of the experiment, the variou dilutions were added at the same time as the bacteria in tw of the wells of each of the 96 plates, and just plain mediu or artificial half strength honey to the other two wells.
These were then sealed and incubated for 24, 48, and 7 hours to see whether the honey had any effect on the formatio of a biofilm.
In the second part of the experiment, honey was adde after 24 hours and incubated for either a further 4 or 2 hours to see if honey restricted growth of the biofilm.
The results showed that Manuka honey strongly inhibite the ‘stickiness’ of the bacteria, and therefore th development of a biofilm.
Even at the lowest dilution, it curbed stickiness by 3 per cent after 48 hours compared with the plain medium an artificial honey.
The study appears in the Journal of Clinical Pathology.
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