4 min readNew DelhiDec 18, 2023 09:18 AM IST
First published on: Dec 16, 2023 at 04:29 PM IST
More than a month after the “Friends” actor Matthew Perry suddenly passed away, the Los Angeles County medical examiner’s office on Friday (December 15) released an autopsy report, saying Perry died from the “acute effects” of ketamine.
The actor was found unresponsive in a hot tub at his home in Los Angeles on October 28, “floating face down in the heated end,” according to the media reports. He was 54-year-old. The autopsy report also mentioned that drowning, coronary artery disease and the effects of an opioid, buprenorphine, had contributed to his death.
In recent years, ketamine has been a subject of widespread debate due to its growing use for treating depression and other serious mental health issues. While some experts and patients call it lifesaving, others say it’s addictive and causes bladder ailments. Here is a look at what ketamine is, and whether it is safe to consume.
What is ketamine?
Ketamine is an anaesthetic that has been listed as a hallucinogen by the US Drug Enforcement Administration. It’s referred to as a “dissociative anaesthetic hallucinogen” because it creates a feeling of detachment from pain and the environment.
In the US, ketamine was first used as an anaesthetic for animals in the 1960s. Around a decade later, the US Food and Drug Administration approved it for humans.
The drug’s use for treating depression and other mental illnesses is recent. Owing to its powerful effects, ketamine is consumed by those patients who haven’t responded to traditional therapies. Ketamine is also used as a recreational drug, popularly known as K or Special K among clubgoers.
How is ketamine consumed?
Mental illness patients usually take ketamine through an IV, nasal spray or tablet once or twice a week for six to eight weeks (some might need it for longer). When it comes to recreational purposes, it is consumed by snorting a white crystalline powder. Ketamine can also be injected or smoked.
What are the effects of ketamine?
In a recent report, The New York Times talked to 40 ketamine patients, many of whom said the drug was like a reset button for the brain.
“During treatment sessions, they experienced pleasant visualisations, sometimes accompanied by a sense of existing outside themselves and melding with the universe. Afterwards, their daily problems seemed less weighty,” according to the report.
It also noted that ketamine garnered popularity as it affects brain receptors that traditional antidepressants do not target. “The psychedelic-like trip, many believe, is integral to the drug’s therapeutic effect,” the report said.
If taken in high doses, the anaesthetic quality of ketamine becomes more pronounced. Some may find it difficult to move and may feel numb, and can experience more graphic hallucinations. “This is sometimes called the ‘k-hole’ by users,” according to The Guardian.
Is it safe to consume ketamine?
It’s hard to say. Some doctors have emphasised that if taken only for medicinal purposes and in the right doses, ketamine is safe to consume and very effective in treating mental illnesses.
However, many patients quoted in the NYT report said the drug can be addictive and, when taken chronically in high doses, can cause severe bladder damage. “There are indications that abuse may also lead to cognitive impairment,” according to the report.
Moreover, there hasn’t been much research on prolonged ketamine treatment to determine if it’s safe or not. There is also a lack of literature on addiction and abuse among medical users.
(With inputs from The New York Times)
Cast member Matthew Perry poses at the premiere for the television series "The Kennedys After Camelot" at The Paley Center for Media in Beverly Hills, California U.S., March 15, 2017. (REUTERS/Mario Anzuoni/File Photo) 
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