June 15, 2021 7:39:48 am
Metformin is a widely prescribed blood sugar-lowering drug. It is often used as an early therapy (in combination with diet and lifestyle changes) for type 2 diabetes.
In a study published online in the journal Immunity, a multi-institution team led by researchers at University of California San Diego (UCSD) School of Medicine identified the molecular mechanism for the anti-inflammatory activity of metformin and found that metformin prevents pulmonary or lung inflammation in mice infected with SARS-CoV-2.
Researchers used a mouse model of acute respiratory distress syndrome (ARDS), a life-threatening condition in which fluids leak into the lungs, making breathing difficult and restricting oxygen supply to essential organs.
ARDS is a frequent cause of death in patients hospitalised with COVID-19.
The researchers found that metformin administered to mice prior to or after exposure to bacterial endotoxin, a surrogate for bacterial pneumonia, resulted in the inhibition of ARDS onset and lessening of its symptoms.
Metformin also produced a marked reduction in mortality in endotoxin-challenged mice and inhibited immunity.
Source: University of California San Diego
📣 The Indian Express is now on Telegram. Click here to join our channel (@indianexpress) and stay updated with the latest headlines
- The Indian Express website has been rated GREEN for its credibility and trustworthiness by Newsguard, a global service that rates news sources for their journalistic standards.