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Wednesday, May 27, 2020

In Italy, going back to work may depend on having the right antibodies

Having the right antibodies to the virus in one’s blood — a potential marker of immunity — may soon determine who gets to work and who does not, who is locked down and who is free.

By: New York Times | Published: April 5, 2020 12:29:03 pm
coronavirus Italy, coronavirus cases italy, coronavirus deaths italy, coronavirus europe, coronavirus news, indian express news A funeral home in Milan, March 24, 2020. Italy was the first European country to announce a nationwide lockdown, which it began on March 9, but the rate of new infections slowed this week – on Friday, there were about 4,500 new cases, less than in recent weeks – leading officials and emergency medical workers alike to talk with guarded optimism. (Alessandro Grassani/The New York Times)

(Written by Jason Horowitz)

There is a growing sense in Italy that the worst may have passed. The weeks of locking down the country, center of the world’s deadliest coronavirus outbreak, may be starting to pay off, as officials announced this past week that the numbers of new infections had plateaued.

That glimmer of hope has turned the conversation to the daunting challenge of when and how to reopen without setting off another cataclysmic wave of contagion. To do so, Italian health officials and some politicians have focused on an idea that might once have been relegated to the realm of dystopian novels and science fiction films.

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Having the right antibodies to the virus in one’s blood — a potential marker of immunity — may soon determine who gets to work and who does not, who is locked down and who is free.

That debate is in some ways ahead of the science. Researchers are uncertain, if hopeful, that antibodies in fact indicate immunity. But that has not stopped politicians from grasping at the idea as they come under increasing pressure to open economies and avoid inducing a widespread economic depression.

The conservative president of the northeastern Veneto region has proposed a special “license” for Italians who possess antibodies that show they have had, and beaten, the virus. The former prime minister, Matteo Renzi, a liberal, has spoken about a “COVID Pass” for the uninfected. Prime Minister Giuseppe Conte said that while the lockdown remained in place, the government had begun working with scientists to determine how to send people who have recuperated back to work.

With its echoes of a “Brave New World,” the debate about how to reopen arrived in earnest this past week in Italy. Like the virus’s crushing toll — some 15,362 dead in Italy as of Saturday evening — the shift is ahead of countries like Spain, Britain and the United States, where the contagion is still on an upswing.

Italy was the first European country to announce a nationwide lockdown, which it began March 9. But the rate of new infections slowed this past week — on Saturday, there were about 4,800 new cases, less than in recent weeks — leading officials and first responders alike to talk with guarded optimism.

“We are beginning to see the light at the end of the tunnel,” said Fabio Arrighini, a supervisor of an ambulance hotline in the Lombardy town of Brescia, which has one of the highest death rates in Italy. “The calls have gone down.”

But the debate over an antibody-based workforce has once again placed Italy at the unfortunate vanguard of Western democracies grappling with the virus, its uncomfortable ethical choices and inevitable aftermath. Such questions have already been raised by the wrenching decisions of doctors to treat the young, with a better chance of life, before the old and sick.

But at some stage, nearly all governments will have to strike a balance between ensuring public safety and getting their countries running again. They may also find themselves weighing what is best for society against individual rights, using biological criteria in ways that almost certainly would be rejected absent the current emergency.

“It looks like it splits humanity into two, the strong and the weak,” said Michela Marzano, a professor of moral philosophy at the Paris Descartes University. “But this is actually the case.”

From an ethical perspective, she argued, the question of using antibodies as a basis for free movement reconciles a utilitarian vision of what is best for society with respect for individual humanity, by protecting “the most fragile, not marginalizing them.”

“It’s not discriminating,” she said. “It’s protecting.”

Scientists in Italy, like their counterparts in Germany, the United States, China and beyond, are already studying whether antibodies are a potential source of protection or immunity from the virus.

China has slowly reopened its economy, focusing on preventing another wave of infection arriving from overseas. In New York, Gov. Andrew Cuomo has envisioned a strategy in which younger people, and people who have antibodies showing they have been cured of the virus, can go back to work.

The British government has floated the idea of “immunity passports,” although it is still struggling to complete even swab tests for an accurate snapshot of current infection levels, and the virus has not been present long enough in the British population to provide enough antibody data.

Italy, by dint of its early and widespread exposure to the virus, has an opportunity to gain insight into how the virus works and the biological properties that protect against it.

Veneto plans to begin collecting 100,000 blood samples from people across the region — first from thousands of health care workers and then public employees — to study in labs the antibodies of people who have the virus and those who have healed from it.

Nowhere in Italy is the pursuit of the antibody strategy more intense than in Veneto. With its wealth of resources, high-profile consultants and biotech presence, it may now be uniquely positioned to influence the global conversation and provide insights for the rest of the world.

The region sits adjacent to the hard-hit Lombardy region, and one of its towns, Vo’, had Italy’s first fatality from the virus and was one of the first towns in the country to be quarantined.

Vo’ also has a relatively homogeneous genetic pool, which may facilitate research, and it has been widely tested. After the outbreak, officials there took the extraordinary step of swab-testing the entire population of 3,000, including people without symptoms.

That helped eliminate an outbreak, and now officials plan to carry out antibody testing and genome sequencing on the entire population to detect patterns in who was and was not susceptible to the virus.

Those results, expected in three or four months, perhaps could shed light on why some remained asymptomatic while others got sick, whether those who didn’t get infected already had antibodies and whether children had something that helped them avoid sickness.

“Italy has at the moment, of course, one of the largest pools of infected people that have recovered from the infection,” said Andrea Crisanti, the top scientific consultant on the virus in Veneto and a professor of microbiology at the University of Padua. He added that it was “a unique and valuable set of information and data.”

Crisanti emphasized the need for a carefully designed strategy to unlock Italy that would make use of contact tracing, protective gear and aggressive testing for post-virus antibodies.

“The planning ahead is one of the most important things,” Crisanti said. “Because it’s easy to lock down.” Without a proper strategy for the path ahead, “the most likely outcome is that the epidemic starts again.”

Here’s a quick Coronavirus guide from Express Explained to keep you updated: What can cause a COVID-19 patient to relapse after recovery? | COVID-19 lockdown has cleaned up the air, but this may not be good news. Here’s why | Can alternative medicine work against the coronavirus? | A five-minute test for COVID-19 has been readied, India may get it too | How India is building up defence during lockdown | Why only a fraction of those with coronavirus suffer acutely | How do healthcare workers protect themselves from getting infected? | What does it take to set up isolation wards?

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