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Small ICMR study finds vaccine mixing safe, offers better immunity

The researchers, however, have made it clear that the evidence is very limited and called for multi-centre randomised clinical trials to conclusively prove the findings.

Written by Anuradha Mascarenhas | Pune |
Updated: October 17, 2021 8:42:21 pm
Delhi govt employees need to take one Covid vaccine dose by Oct 15, else no entry in office: OrderThis study comes months after several people in Uttar Pradesh received Covishield as the first dose followed by inadvertent administration of Covaxin as the second dose. (File)

A limited study conducted by the Indian Council of Medical Research (ICMR) among 18 participants has found that a combination of Covishield and Covaxin shots is safe and, in fact, offers better immunogenicity than two doses of the same vaccine.

The researchers, however, have made it clear that the evidence is very limited and called for multi-centre randomised clinical trials to conclusively prove the findings.

”The reactogenicity profile of the participants of the heterologous group demonstrated that mixing of the two vaccines derived from different platforms is safe,” said the study, conducted by ICMR- Regional Medical Research Centre and ICMR-National Institute of Virology. It has been accepted for publication in the International Journal of Travel Medicine.

This study comes months after several people in Uttar Pradesh received Covishield as the first dose followed by inadvertent administration of Covaxin as the second dose.

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Dr Rajni Kant, director of ICMR’s Regional Medical Research Centre, Gorakhpur, and lead author, told The Indian Express that this was a small study involving 18 participants.

They received a vaccination regimen of Covishield followed by Covaxin. The participants did not report any adverse event following immunization and demonstrated high antibody response.

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