Real Madrid are joint second in the table with Celta Vigo and Barcelona on 15 points and a win would have seen them leapfrog Villarreal
Luciano Vietto slotted the ball home with seven minutes to go after Karim Benzema had given visitors Real the lead early on.
With the goal flow slowed, Barcelona’s defending has come under the spotlight.
Barcelona remained with 15 points from seven rounds, dropping from second to third place in the standings.
The ex-England defender noted Cristiano Ronaldo’s growth since arriving at Manchester United as a teenager.
Real Madrid are now two points behind surprise leaders Villarreal after six games.
Lionel Messi was ruled out for up to two months after damaging knee ligaments.
Barcelona will also miss the likes of Claudio Bravo, Thomas Vermaelen, Sandro Ramirez.
Atletico de Madrid controlled the game but they eased off for long spells against a side incapable of putting them under pressure.
Keylor Navas was close to moving English Premier League club Manchester United, but the transfer was not successful.
As Barcelona face Celta Vigo, here are other things to look for in the Spanish league this week.
Real Madrid beat Granada 1-0 while Atletico win 2-0 at Eibar; Valencia held 0-0 at home to Real Betis.
Cristiano Ronaldo hit five goals in a match for the first time when Real hammered Granada 9-1 at the Bernabeu last season.
Cristiano Ronaldo scores five goals as Real Madrid beat Espanyol 6-0 in Spanish La Liga.
Lionel Messi was included in Barcelona squad list for their La Liga clash against Atletico Madrid.
Real Madrid president Florentino Perez said Manchester United lacked ‘negotiating experience.’
Gareth Bale overshadowed an out-of-sorts Cristiano Ronaldo on a night where Real Madrid pumped in five goals.
Neymar missed this month’s European and Spanish Super Cups, as well as last weekend’s 1-0 win at Athletic Bilbao.
Real Madrid’s hopes of beating Real Betis could be boosted by the return from injury of Karim Benzema.
Real Madrid’s new coach Rafa Benitez is under pressure early in his stint with the club as they face Real Betis in their League opener.
Atletico de Madrid got their La Liga campaign up and running in less than a convincing fashion.
Real begin their latest La Liga campaign on Sunday at promoted Sporting Gijon.
Facing trouble to field the right combination, Jordi Alba’s presence will help Barcelona’s prospects.
Pepe, 32, has helped Madrid win the Champions League and two Spanish league titles in eight seasons.
Referee Carlos Velasco Carballo acted after Pique strode angrily up to the linesman and yelled in his face.
Rafa Benitez’s Real Madrid will kick off their season against Sporting Gijon on Sunday.
The return leg is at the Nou Camp on Monday but even for Lionel Messi and company it may be asking too much to win.
Turkey captain Arda joined Barca this week after four seasons at Atletico Madrid.
Alves spoke angrily at a news conference last month when he said he felt that he was not appreciated at Barcelona.
The Brazilian right-back was being linked to a move to Manchester United this summer.
Benitez will be tasked with ending Madrid’s dismal record of one Spanish title in seven seasons.
Former Liverpool, Inter Milan and Chelsea manager Benitez has already announced his exit from Serie A side Napoli.
The Brazilian was treated to a chorus of boos from the Athletic fans and given some rough treatment by rival defenders.
Spanish champions look to win the Champions League against Juventus on June 6 to complete the treble.
Barca’s South American attacking trio have netted a Spanish record 120 goals in all competitions this season.
After the match, Portugal captain Ronaldo posted a message on his Twitter feed with a photograph of himself and Ancelotti.