Australian seamer Mitchell Johnson took 4/42 wickets to rattle the South African batting.
David Warner says South Africa generated reverse swing in 2nd Test because deVilliers was scuffing up the ball.
Graeme Smith, though, was annoyed with the number of catches his side put down in Port Elizabeth.
Australia go from 152/1 to 216 all out to lose PE Test in final over of Sunday, a day before a wash-out was forecast.
Reduced to 11/2, South Africa indebted to two big stands forged by Elgar to take side to 214/5 by stumps on Day 1.
Mauled by Australia in first Test, South Africa will look to avoid losing their first series in five years.
The Australians were clearly superior in all three disciplines in their first Test win.
Mitchell Johnson proved the central figure on a day of dominance for Australia.
Australia chased down a target of 310 to share the series.
Dale Steyn was the architect of another Australian batting collapse as South Africa ended the second day of the second Test trailing by just 30 runs
Newlands Test evenly poised after manic Day 2 witnesses 4 innings and 23 wickets