Manchester City suffered from deja vu as Luis Suarez’s double gave Barcelona a 2-1 first leg lead.
A year ago at the same stage City bowed out 4-1 on aggregate against the four-times European champions.
Manchester City take on Barcelona and Juventus face Dortmund as the Champions League gets into its stride.
Liverpool’s late victory over Spurs on Tuesday has opened up a riveting race for the Champions League spots.
City’s chances of winning the League title will almost certainly end if they lose at Stoke on Wednesday.
West Ham climbed above Liverpool into seventh with 36 points from 22 games.
Leaders Chelsea and champions Manchester City match each other stride for stride.
Lampard initially joined City on loan for six months from New York City FC after leaving Chelsea at the end of last season.
Chelsea, Manchester City continue winning run; Manchester United keep pace with 3-1 win over Newcastle.
Mourinho is also confident that Eden Hazard will sign a new contract at Stamford Bridge.
Arsenal manager Arsene Wenger will face his old club AS Monaco for the first time.
After such a tremendous start to the season, Southampton’s woes continued with a fourth consecutive defeat.
With the attacking flair that helped them claim the Premier League title last season put to one side, City produced a gladiatorial performance that conquered Roma.
Two second-half goals from English champions help them progress to the knockout stage of Champions Trophy.
Roma, City and CSKA all have five points after mediocre campaigns in a group dominated by Bayern.