Reus put the visitors ahead after 39 minutes and Mueller doubled their lead before the break.
Brazil have won all eight matches under coach Dunga since finishing fourth in last year’s World Cup on home soil.
Despite Messi’s absence Argentina managed to hand on to a 2-0 win.
Suarez broke free from Madrid’s defense to restore Barcelona’s lead in the 56th minute.
Juan Mata’s marvellous volley helped Manchester United beat Liverpool in the race for Champions League qualification.
Menez scored twice to help beleaguered AC Milan beat Cagliari 3-1 in front of a sparse San Siro crowd.
City were handed a boost after 90 seconds at the Etihad when West Brom defender Gareth McAuley was sent off.
Real Madrid will take on crosstown rival Atletico Madrid in the quarterfinals of the Champions League.
The contest also highlighted the gulf that has opened up between Spanish and English football in club football.
Arsenal won the second leg but lost on away goal 3-3 aggregate against Monaco in the Champions League.
India held a dominant Nepal to a goalless draw in their 2018 World Cup qualifying first round second leg match.
These little Luiz and Silva look-alikes kick the ball like a pro and nail the post-goal celebration slide perfectly.
Bale struck a brace to end his drought and Real Madrid’s winless run with a 2-0 victory over Levante.
Costa opened the scoring for Chelsea but Southampton deservedly equalised eight minutes later.
Lionel Messi moved ahead of Cristiano Ronaldo in scoring charts as Barcelona won 2-0 at Eibar to stay top.