Sunderland will have the opportunity to end in-form Chelsea’s run of 19 undefeated matches.
United have struggled in adapting from their usual 4 at the back to Van Gaal’s preferred 3.
The trio has rarely featured for City under manager Manuel Pelligrini and their future with the team looks grim.
Sturridge breaks Liverpool out of jail with late winner vs Southampton; Champs City get off to winning start.
Insidious threat — due to its currency at this World Cup — is the mental and physical state of its players.
City beat West Ham 2-0 to win English soccer’s most coveted trophy in Pellegrini’s first season as manager.
Man City won the Premier League for the second time in three seasons, after a comfortable 2-0 victory over West Ham.
City’s title win came after Aguero’s dramatic late winner against QPR on the final day of the 2011-12 season.
City need just a draw against West Ham United to win their second league title in three years.
Aguero has scored 17 goals in 22 league appearances this season, but has missed many games with calf and hamstring injuries.
The title race is realistically down to Manchester City and Liverpool now, after Chelsea’s latest stumble.
They moved to 80 points, five ahead of Chelsea who suffered a shock 2-1 defeat by Sunderland on Saturday.
Striker can help Liverpool edge closer to EPL title this weekend if he can add to his 29 goals for the season.
Manchester City next face 16th-placed West Bromwich, who are desperately trying to stave off relegation.
Man City failed to respond to their 3-2 drubbing by Liverpool on Sunday and stayed third in the table.