A powerful blast rocked the congested Kachari area of Quetta near the premises of the heavily guarded city district courts.
Officials said most of those killed were daily wage labourers, adding that eight of the injured were in a critical condition.
The workers who were going to a health centre were without any security cover at the time of the attack.
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Several people were also reported injured in the explosion.
Director of the National Seismic Centre said the epicentre was in Awaran,more aftershocks expected.
An army helicopter carrying relief goods to the quake-hit area hit by the suspected militants.
Island is 60 to 70 feet above sea level and its land mass measures about 120 metres.
Sharif expressed grief at the loss of lives and property due to the earthquake.
The reason behind the firing has not yet been ascertained.