Barcelona beat Villarreal 6-2 on aggregate while Athletic Bilbao beat Espanyol 3-1 on aggregate.
Behind Chelsea and City, victories for Arsenal, United and Liverpool kept the CL qualifications tight.
It was Villa's first win since Dec. 7 and ended a seven-match losing streak in the Premier League.
Real Madrid stumbled to a costly 1-1 draw with Villarreal at home on Sunday to tighten the La Liga title race.
Philippe Coutinho's winner against Manchester City at Anfield led Liverpool to a 2-1 win against Manchester City.
Captain John Terry led Chelsea to its first trophy in two years scoring the opener in a 2-0 victory over Tottenham.
Barcelona's 3-1 win was overshadowed by Alberto Bueno netting four goals in Rayo Vallecano's victory.
Rooney scored twice in United's 2-0 win at the Old Trafford.
Louis van Gaal says his expensively assembled squad has no prolific strikers to compare with top teams.
Liverpool were the highest profile casualties of the last 32, where holders Sevilla came through a testing encounter.
It was a night of upsets as two top teams were edged out in Champions League first leg.
Mizoram keeps its fingers crossed for the the third consecutive national gold.
Manchester City suffered from deja vu as Luis Suarez's double gave Barcelona a 2-1 first leg lead.
A year ago at the same stage City bowed out 4-1 on aggregate against the four-times European champions.
Manchester City take on Barcelona and Juventus face Dortmund as the Champions League gets into its stride.
Liverpool moved two points off the top four in the Premier League with a 2-0 win at Southampton on Sunday.
Cristiano Ronaldo and Karim Benzema scored to give Real Madrid a 2-0 win at Elche on Sunday.
Barcelona could have moved to the top of league table but unfortunately it wasn't to be.
Chelsea were held to a 1-1 draw by lowly Burnley as rivals Manchester City thrashed Newcastle United 5-0.
The victim of a racist incident involving Chelsea football fans will now lodge an official complaint with police.
The world player of the year headed in after 26 minutes for his 73rd Champions League goal .
Chelsea fans chant "we're racist, we're racist, and that's the way we like it" in viral video.
Xabi Alonso was sent off in his 100th Champions League game as 10-man Bayern was held to a 0-0 draw by Shakhtar.
PSG salvaged a 1-1 home draw against Chelsea in their last-16 first leg on Tuesday.
The champions league is back in town on as the knockout stages commence and we take a look at what is to come.
PSG’s midfield faces a tough test against Chelsea, and the task could be made even harder without Matuidi.
Lionel Messi kept up his scoring streak by netting a hat trick as Barcelona swept aside Levante 5-0.
Real Madrid needed goals from Isoand Karim Benzema to beat a determined Deportivo La Coruna outfit.
Dortmund finally struck five minutes after the restart as Neven Subotic beat his marker to head in a corner.
Liverpool's late victory over Spurs on Tuesday has opened up a riveting race for the Champions League spots.
Rodgers may not want to start Daniel Sturridge for the second time in five days.
Luis Suarez had the Barcelona fans chanting his name after he set up Lionel Messi to score the opening goal.
Chelsea were frustrated before Brazilian Willian struck from 20 metres in the 89th minute.
TV group Sky has agreed to pay 4.2 billion pounds ($6.4 billion) to show 126 live Premier League matches.
Arsenal have 45 points from 25 games, two clear of sixth placed Spurs and three ahead of Liverpool.
Odegaard is among the 23 names that Madrid has registered for the next round of the Champions League.