Germany goalkeeper Manuel Neuer will miss the World Cup qualifier against San Marino after feeling unwell shortly before the team’s departure on Wednesday.
The German football federation says midfielder Julian Brandt also stayed home, down with the flu.
Germany was aready missing midfielders Toni Kroos and Julian Draxler, as well as defender Jerome Boateng, because of various injuries.
After playing in San Marino on Friday, Germany meets Italy in a friendly on Tuesday in Milan.
Germany leads its group with three wins from three matches and is heavily favored against San Marino.
Only the group winners qualify directly for the 2018 tournament in Russia, where Germany hopes to defend its World Cup title.