People who use statin drugs to lower their cholesterol sometimes complain of muscle pain and soreness. But a new study suggests that in some cases these side effects may be a result of combining statins with other medications.
The research found that people taking statins had double the risk of muscle pain when they were prescribed various other drugs,and often these side effects were what prompted people to stop taking statins. People in the study who quit using statins because they could not tolerate them were,on average,taking as many as three other drugs that could increase the risk of side effects.
As patients are proactive about knowing the potential drugs that could cause interactions,we,as practitioners,could reduce the risk of these muscle pains and side effects, said Matthew K Ito,a professor at the Oregon State University College of Pharmacy and the president of the National Lipid Association,a nonprofit group representing specialists in lipid disorders that funded the study.
Statins lower LDL cholesterol and can reduce inflammation in arteries. But some studies suggest that as many as one of five people taking them experience aches,weakness and general soreness in their muscles,a condition referred to as myopathy.
Scientists suspect this occurs because statins block the production of CoQ10,a molecule the body uses to generate energy.
In the new study,which was published in The Journal of Clinical Lipidology,Dr Ito and his colleagues examined data on more than 10,000 current and former statin users. Roughly a third reported having experienced muscle pain that began or worsened when they took statins,and about 60 per cent of people who stopped taking them said that these side effects were the reason.
Because statins are widely used by older adults,many of the people taking them are on other medications for diabetes,hypertension,gout or other chronic conditions,said Dr James A Underberg,the director of the Bellevue Hospital Lipid Clinic in New York,a lipidologist who was not involved in the research.
Doctors often decide which statins to prescribe based on cost and insurance coverage. But the new research suggests that prescribing based on the potential for drug interactions may affect whether patients actually take them or not.
If you think about the drug interactions,then you can better predict who is going to get into trouble and who is not,and maybe you should be using that information to select your drugs, Dr Underberg said. Instead of just saying,Im going to choose this drug because its the cheapest or the one I have in my office, you should think about which one makes sense based on the drug interactions that are at play.