Researchers have found a protein in the blood of pregnant women that can predict if they are likely to have a fetus that doesnt grow properly,and thus has a high risk of stillbirth and long-term health complications.
The research,led by Dr. Andree Gruslin,could lead to a widely available blood test and could help develop ways for improving the outcomes of women and their children who face this risk estimated to be as many as one of every 20 pregnancies.
Dr. Gruslins study focuses on a protein called Insulin Growth Factor Binding Protein 4 (IGFBP-4).
While this protein has been linked to pregnancy before,this study is the first to demonstrate its important role in human pregnancy complications.
A key part of the study involved examining IGFBP-4 levels in first trimester blood samples from women who participated in a large study of pregnancies and newborns called the Ottawa and Kingston (OaK) birth cohort.
Dr. Gruslin found that women with high levels of IGFBP-4 were 22 times more likely to give birth to tiny babies (defined as the smallest five per cent by weight for their gestational age),than women with normal levels of IGFBP-4. This part of the study involved a total of 72 women half with tiny babies and half with normal weight babies.
Usually,we dont find out until later in a pregnancy that a fetus isnt growing properly,but this test can tell us in the first trimester if theres likely to be a problem, said Dr. Gruslin,a Scientist at OHRI,High Risk Obstetrician at The Ottawa Hospital and Professor in the Faculty of Medicine at uOttawa.
By identifying these high-risk pregnancies early on,we will be able to monitor these women more closely and hopefully help them deliver a healthier baby, she said.
The IGFBP-4 blood test is still experimental,but Dr. Gruslin hopes to develop a refined version that could be made available to all pregnant women within the next couple of years.
She also hopes that her studies on IGFBP-4 could lead to new approaches that would improve fetal growth in high-risk pregnancies.
This condition,called Fetal Growth Restriction or Intrauterine Growth Restriction,is thought to affect three to five per cent of all pregnancies,and cause close to half of all stillbirths.