• Associate Sponsor

This new insulin pill could make diabetes treatment ‘painless’

Insulin has been successfully encapsulated using Cholestosomes that can be administered orally with tiny vesicles that can deliver insulin where it needs to go without injecting.

By: IANS | New York | Published: August 24, 2016 7:46 pm
insulin, diabetes, insulin pills, oral insulin, diabetes treatment, diabetes pills, health news, latest health news This new oral way of taking insulin will be well-received by those who need to take regular insulin shots. (Source: Pixabay)

US scientists have developed an oral method of administering insulin that can be a less painful alternative to millions of people worldwide with diabetes who have to inject themselves with the drug to manage their blood-sugar levels.

The team has successfully encapsulated insulin using Cholestosomes – a neutral, lipid-based particle – that can be administered orally with tiny vesicles that can deliver insulin where it needs to go without injecting.

The biggest obstacle to delivering insulin orally is ushering it through the stomach intact. Proteins such as insulin are no match for the harsh, highly acidic environment of the stomach. They degrade before they get a chance to move into the intestines and then the bloodstream where they’re needed, the study said.

However, the new vesicles that are made of naturally occurring lipid molecules are normal building blocks of fats, the researchers said, adding that they are unlike other lipid-based drug carriers, called liposomes.

“Most liposomes need to be packaged in a polymer coating for protection. Here, we are just using simple lipid esters to make vesicles with the drug molecules inside,” said lead researcher Mary McCourt, Professor at Niagara University in New York, US.

Computer modelling showed that once the lipids are assembled into spheres, they form neutral particles resistant to attack from stomach acids. Drugs can be loaded inside, and the tiny packages can pass through the stomach without degrading.

When cholestosomes reach the intestines, the body recognises them as something to be absorbed. The vesicles pass through the intestines, into the bloodstream, and then cells take them in and break them apart, releasing insulin.

Studies with rats showed that certain formulations of cholestosomes loaded with insulin have high bioavailability, which means the vesicles travel into the bloodstream where the insulin needs to be, the researchers concluded.

The results were presented at the 252nd National Meeting and Exposition of the American Chemical Society (ACS), in Philadelphia, recently.

For all the latest Lifestyle News, download Indian Express App

  1. C
    Dec 14, 2017 at 10:17 am
    Prescription Pad is a clinic management softwrae provides all types of facilities for hospitals doctors. The best part of the software is Prescription writing facilities for doctors drug b interaction checker tool. For more info please visit: prescriptionpad(dot)in
    1. C
      Oct 21, 2016 at 11:13 pm
      I want to say thanks to Doctor telson for helping me cure my diabetes type 2. Brethren, i have suffered diabeteslt;br/gt;lt;br/gt;for a long period of time, i have tried so many remedy, but known seems to work. But i had contact with a herbal doctorlt;br/gt;lt;br/gt;who i saw so many people testifying on how they were all cured of their various disease and viruses by this doctor. So ilt;br/gt;lt;br/gt;explained my entire problem to him, and he promised to cure me. So i gave him all benefit of doubt, and behold he preparedlt;br/gt;lt;br/gt;the herbal mixture, and send it to me in my country. Today, i am proud to say i am diabetes free, and my sugar level haslt;br/gt;lt;br/gt;been restored to normal. So in case you are out there suffering from diabetes and other disease and or virus, i want tolt;br/gt;lt;br/gt;tell you to quickly contact Doctor telson for your cure.lt;br/gt;lt;br/gt;SOME OF WHAT HE CAN PERFECTLY CURE 100%lt;br/gt;1. Miscarriagelt;br/gt;2.Diabeteslt;br/gt;3.PREGNANCY PROBLEMlt;br/gt;4. HERPESlt;br/gt;5. LOW SPERM COUNTlt;br/gt;6. MENOPAUSE DISEASElt;br/gt;7. EPILEPSYlt;br/gt;8. ASEPSISlt;br/gt;9. CANCERlt;br/gt;10. ANXIETY DEPRESSIONlt;br/gt;11. spiritual power lt;br/gt;12. SHORT SIGHTEDNESS PROBLEMlt;br/gt;14. Male menopauselt;br/gt;15. Menopause – malelt;br/gt;16. Menopause – perilt;br/gt;17. Menstruation problemslt;br/gt;18. Mercury Poisoninglt;br/gt;19. Migrainelt;br/gt;20. premature ejaculationlt;br/gt;21. Mites (demodex mites)lt;br/gt;22. Mites (scabies mites)lt;br/gt;23. Motion sicknesslt;br/gt;24. Mouth ulcerlt;br/gt;25. MRSAlt;br/gt;26.HIV/AIDSlt;br/gt;27. LA FEVERlt;br/gt;28. GONORRHEA lt;br/gt; 29.looking for job lt;br/gt; His email is () you can also calllt;br/gt;lt;br/gt;him on ( 2348138295517).
      1. D
        Aug 27, 2016 at 5:01 pm
        HI THERElt;br/gt;It is important to maintain lt;br/gt;Healthy food habit and avoid such a bad disease like Diabetes.lt;br/gt;I followed a great system and i get good result to reduce my Diabetes.lt;br/gt;Get The Complete Diabetes Destroyer System.lt;br/gt;Reverse Your Diabetes With The Pancreast Jumpstart Protocol.lt;br/gt;Get It Now..==gt;gt;