Thursday, Oct 23, 2014

Scorpion’s venom can help detect cancer

scorpio-main The compound called chlorotoxin is found in the venom of the death stalker scorpion known as leiurus quinquestriatus. (Source: Thinkstock Images)
Indo-Asian News Service | Washington | Posted: July 8, 2014 12:43 pm

In what can alter the course of cancer treatment in the near future, researchers have found a compound that appears to pinpoint all of the malignant cells in a patient’s body.

The twist is that the compound’s main ingredient is a molecule that is found in the sting of a deadly scorpion.

The compound called chlorotoxin is found in the venom of the death stalker scorpion known as leiurus quinquestriatus.

It gives malignant cells a bright fluorescent sheen so surgeons can easily spot them, wired.com reported.

“A scorpion-venom concoction that makes tumours glow sounded almost too outlandish to be true in the beginning. But with generous donations from individuals, the fluorescent scorpion toxin is now in Phase I clinical trials,” informed Jim Olson from the renowned Seattle-based Fred Hutchinson Cancer Research Centre that developed the technique, called “Tumour Paint”.

Scorpion venoms are cocktails of numerous individual toxins that attack different targets within a victim’s body.

Olson and his team found that chlorotoxin did not attach just to brain tumours — it grabbed onto all sorts of cancers, from those that affect the skin to those that destroy the lungs.

In lab experiments, Olson began to inject fluorescent-tipped chlorotoxin into mice — the compound lit up cancer cells that no other technology could identify.

In one instance, the chlorotoxin illuminated a clump of just 200 malignant cells that were burrowed deep within a wad of fat.

“That was the point we learned that the technology was far more sensitive than an MRI,” Olson was quoted as saying.

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