Saturday, Oct 25, 2014

Scientists find new way to observe ‘good’ brown fat

Press Trust of India | London | Posted: April 18, 2014 3:14 pm

Scientists have for the first time used MRI scanning to confirm the presence of ‘brown fat’ in a living adult, an advance that paves way for new therapies to fight diabetes and obesity.

Researchers from Warwick Medical School and University Hospitals Coventry and Warwickshire National Health Service (NHS) Trust used a magnetic resonance imaging (MRI) based method to identify and confirm the presence of brown adipose tissue in a living adult.

Brown fat has become a hot topic for scientists due its ability to use energy and burn calories, helping to keep weight in check.

“This is an exciting area of study that requires further research and discovery,” said Dr Thomas Barber, from the Department of Metabolic and Vascular Health at Warwick Medical School.

“The potential is there for us to develop safe and effective ways of activating this brown fat to promote weight loss and increase energy expenditure – but we need more data to be able to get to that point.

“This particular proof of concept is key, as it allows us to pursue MRI techniques in future assessments and gather this required information,” Barber said.

The study, published in The Journal of Clinical Endocrinology and Metabolism, outlines the benefits of using MRI scans over the existing method of positron emission tomography (PET).

While PET does show brown fat activity, it is subject to a number of limitations including the challenge of signal variability from a changing environmental temperature.

Unlike the PET data which only displays activity, the MRI can show brown fat content whether active or not – providing a detailed insight into where it can be found in the adult body.

This information could prove vital in the creation of future therapies that seek to activate deposits of brown fat, researchers said.

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